3MXW

Crystal structure Sonic hedgehog bound to the 5E1 fab fragment

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0007267	biological_process	cell-cell signaling
A	0007275	biological_process	multicellular organism development

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN A 400

Chain	Residue
A	SO43
A	HIS140
A	ASP147
A	GLU176
A	HIS182
A	HOH334

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site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 401

Chain	Residue
A	THR125
A	GLU126
A	GLU89
A	GLU90
A	ASP95

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site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 402

Chain	Residue
A	GLU90
A	GLU126
A	ASP129
A	ASP131
A	HOH373

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site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 1

Chain	Residue
A	ARG101
A	LYS105

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site_id	AC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE SO4 A 3

Chain	Residue
A	HOH7
A	HIS134
A	SER135
A	SER138
A	HIS140
A	GLU176
A	HIS182
A	HOH334
A	ZN400
A	HOH436

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site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 L 215

Chain	Residue
L	LYS39
L	GLN42
L	LYS45
L	HOH256
L	HOH446

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Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH

Chain	Residue	Details
H	TYR194-HIS200
L	TYR192-HIS198

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20504762","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3MXW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10753901","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20504762","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3M1N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3MXW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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