6QU9

Fab fragment of an antibody that inhibits polymerisation of alpha-1-antitrypsin

Summary for 6QU9

Entry DOI	10.2210/pdb6qu9/pdb
EMDB information	4620 4631 4632
Descriptor	FAB 4B12 heavy chain, FAB 4B12 light chain, SULFATE ION, ... (6 entities in total)
Functional Keywords	alpha-1 antitrypsin, z variant, polymers, protein aggregation, monoclonal antibody, fab fragment, copd, protease inhibitor, glycoprotein, deficiency, protein binding
Biological source	Mus musculus (House mouse) More
Total number of polymer chains	4
Total formula weight	94115.64
Authors	Jagger, A.M.,Heyer-Chauhan, N.,Lomas, D.A.,Irving, J.A. (deposition date: 2019-02-26, release date: 2020-03-18, Last modification date: 2020-11-04)
Primary citation	Faull, S.V.,Elliston, E.L.K.,Gooptu, B.,Jagger, A.M.,Aldobiyan, I.,Redzej, A.,Badaoui, M.,Heyer-Chauhan, N.,Rashid, S.T.,Reynolds, G.M.,Adams, D.H.,Miranda, E.,Orlova, E.V.,Irving, J.A.,Lomas, D.A. The structural basis for Z alpha 1 -antitrypsin polymerization in the liver. Sci Adv, 6:-, 2020 Cited by PubMed: 33087346 DOI: 10.1126/sciadv.abc1370 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation