8DT8

LM18/Nb136 bispecific tetra-nanobody immunoglobulin in complex with SARS-CoV-2-6P-Mut7 S protein (focused refinement)

Summary for 8DT8

• Entry DOI: 10.2210/pdb8dt8/pdb
• EMDB information: 27692
• Descriptor: Spike glycoprotein, LM18 nanobody, Nb136 nanobody, ... (4 entities in total)
• Functional Keywords: nanobody, bispecific nanobody, coronavirus, antibody engineering, viral protein
• Biological source: Severe acute respiratory syndrome coronavirus 2; More
• Total number of polymer chains: 5
• Total formula weight: 454536.04

Authors

Ozorowski, G.,Turner, H.L.,Ward, A.B. (deposition date: 2022-07-25, release date: 2023-06-14)

• Primary citation: Misson Mindrebo, L.,Liu, H.,Ozorowski, G.,Tran, Q.,Woehl, J.,Khalek, I.,Smith, J.M.,Barman, S.,Zhao, F.,Keating, C.,Limbo, O.,Verma, M.,Liu, J.,Stanfield, R.L.,Zhu, X.,Turner, H.L.,Sok, D.,Huang, P.S.,Burton, D.R.,Ward, A.B.,Wilson, I.A.,Jardine, J.G.; Fully synthetic platform to rapidly generate tetravalent bispecific nanobody-based immunoglobulins.; Proc.Natl.Acad.Sci.USA, 120:e2216612120-e2216612120, 2023; PubMed: 37276407; DOI: 10.1073/pnas.2216612120

Experimental method

ELECTRON MICROSCOPY (3.34 Å)