PDB: 757 件ウェブページステータス検索Chemie searchBIRD

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5LXS	Tubulin-KS-1-199-32 complex 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Prota, A.E, Steinmetz, M.O. 登録日 2016-09-22 公開日 2017-09-20 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural Basis of Microtubule Stabilization by Discodermolide. Chembiochem, 18, 2017
5LP6	Crystal structure of Tubulin-Stathmin-TTL-Thiocolchicine Complex 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, CHLORIDE ION, ... 著者 Marangon, J, Christodoulou, M, Casagrande, F, Tiana, G, Dalla Via, L, Aliverti, A, Passarella, D, Cappelletti, G, Ricagno, S. 登録日 2016-08-11 公開日 2016-09-21 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Tools for the rational design of bivalent microtubule-targeting drugs. Biochem. Biophys. Res. Commun., 479, 2016
5LOV	DZ-2384 tubulin complex 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, DZ 2384, ... 著者 Prota, A.E, Steinmetz, M.O, Shore, G.C, Brouhard, G, Roulston, A. 登録日 2016-08-10 公開日 2016-11-30 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 The synthetic diazonamide DZ-2384 has distinct effects on microtubule curvature and dynamics without neurotoxicity. Sci Transl Med, 8, 2016
5LA6	Tubulin-pironetin complex 分子名称: CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... 著者 Prota, A.E, Setter, J, Waight, A.B, Bargsten, K, Murga, J, Diaz, J.F, Steinmetz, M.O. 登録日 2016-06-13 公開日 2016-07-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Pironetin Binds Covalently to alpha Cys316 and Perturbs a Major Loop and Helix of alpha-Tubulin to Inhibit Microtubule Formation. J.Mol.Biol., 428, 2016
5KX5	Crystal structure of tubulin-stathmin-TTL-Compound 11 complex 分子名称: (2~{S},4~{R})-4-[[2-[(1~{R},3~{R})-1-acetyloxy-3-[[(2~{S},3~{S})-2-[[(2~{R})-1,2-dimethylpyrrolidin-2-yl]carbonylamino]-3-methyl-pentanoyl]-methyl-amino]-4-methyl-pentyl]-1,3-thiazol-4-yl]carbonylamino]-5-(4-aminophenyl)-2-methyl-pentanoic acid, ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, ... 著者 Parris, K. 登録日 2016-07-20 公開日 2016-12-28 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Design, Synthesis, and Cytotoxic Evaluation of Novel Tubulysin Analogues as ADC Payloads. ACS Med Chem Lett, 7, 2016
5KMG	Near-atomic cryo-EM structure of PRC1 bound to the microtubule 分子名称: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Kellogg, E.H, Howes, S, Ti, S.-C, Ramirez-Aportela, E, Kapoor, T.M, Chacon, P, Nogales, E. 登録日 2016-06-27 公開日 2016-08-03 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Near-atomic cryo-EM structure of PRC1 bound to the microtubule. Proc.Natl.Acad.Sci.USA, 113, 2016
5JVD	Tubulin-TUB092 complex 分子名称: (2E)-3-(3-hydroxy-4-methoxyphenyl)-1-(7-methoxy-2H-1,3-benzodioxol-5-yl)-2-methylprop-2-en-1-one, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... 著者 Canela, M.-D, Noppen, S, Bueno, O, Prota, A.E, Bargsten, K, Saez-Calvo, G, Jimeno, M.-L, Benkheil, M, Ribatti, D, Velazquez, S, Camarasa, M.-J, Diaz, J.F, Steinmetz, M.O, Priego, E.-M, Perez-Perez, M.-J, Liekens, S. 登録日 2016-05-11 公開日 2016-06-08 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.393 Å) 主引用文献 Antivascular and antitumor properties of the tubulin-binding chalcone TUB091. Oncotarget, 8, 2017
5JQG	An apo tubulin-RB-TTL complex structure used for side-by-side comparison 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, CHLORIDE ION, ... 著者 Wang, Y.X, Naismith, J.H, Zhu, X. 登録日 2016-05-04 公開日 2016-05-18 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.24 Å) 主引用文献 Pironetin reacts covalently with cysteine-316 of alpha-tubulin to destabilize microtubule Nat Commun, 7, 2016
5JH7	Tubulin-Eribulin complex 分子名称: (1S,3S,6S,9S,12S,14R,16R,18S,20R,21R,22S,26R,29S,31R,32S,33R,35R,36S)-20-[(2S)-3-amino-2-hydroxypropyl]-21-methoxy-14-methyl-8,15-dimethylidene-2,19,30,34,37,39,40,41-octaoxanonacyclo[24.9.2.1~3,32~.1~3,33~.1~6,9~.1~12,16~.0~18,22~.0~29,36~.0~31,35~]hentetracontan-24-one (non-preferred name), 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... 著者 Doodhi, H, Prota, A.E, Rodriguez-Garcia, R, Xiao, H, Custar, D.W, Bargsten, K, Katrukha, E.A, Hilbert, M, Hua, S, Jiang, K, Grigoriev, I, Yang, C.-P.H, Cox, D, Band Horwitz, S, Kapitein, L.C, Akhmanova, A, Steinmetz, M.O. 登録日 2016-04-20 公開日 2016-06-29 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Termination of Protofilament Elongation by Eribulin Induces Lattice Defects that Promote Microtubule Catastrophes. Curr.Biol., 26, 2016
5JCO	Structure and dynamics of single-isoform recombinant neuronal human tubulin 分子名称: GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, ... 著者 Vemu, A, Atherton, J, Spector, J.O, Szyk, A, Moores, C.A, Roll-Mecak, A. 登録日 2016-04-15 公開日 2016-05-04 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Structure and Dynamics of Single-isoform Recombinant Neuronal Human Tubulin. J.Biol.Chem., 291, 2016
5JCB	Microtubule depolymerizing agent podophyllotoxin derivative YJTSF1 分子名称: (5R,5aR,8aS,9R)-9-[(4H-1,2,4-triazol-3-yl)sulfanyl]-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tetrahydro-2H-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... 著者 Guan, Z, Zhao, W, Yin, P. 登録日 2016-04-14 公開日 2017-09-27 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural Insights into the Inhibition of Tubulin by the Antitumor Agent 4 beta-(1,2,4-triazol-3-ylthio)-4-deoxypodophyllotoxin. ACS Chem. Biol., 12, 2017
5J2U	Tubulin-MMAF complex 分子名称: CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... 著者 Waight, A.B, Bargsten, K, Doronina, S, Steinmetz, M.O, Sussman, D, Prota, A.E. 登録日 2016-03-30 公開日 2016-08-17 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural Basis of Microtubule Destabilization by Potent Auristatin Anti-Mitotics. Plos One, 11, 2016
5J2T	Tubulin-vinblastine complex 分子名称: (2ALPHA,2'BETA,3BETA,4ALPHA,5BETA)-VINCALEUKOBLASTINE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... 著者 Waight, A.B, Bargsten, K, Doronina, S, Steinmetz, M.O, Sussman, D, Prota, A.E. 登録日 2016-03-30 公開日 2016-08-17 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural Basis of Microtubule Destabilization by Potent Auristatin Anti-Mitotics. Plos One, 11, 2016
5IYZ	Tubulin-MMAE complex 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Waight, A.B, Bargsten, K, Doronina, S, Steinmetz, M.O, Sussman, D, Prota, A.E. 登録日 2016-03-24 公開日 2016-08-17 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural Basis of Microtubule Destabilization by Potent Auristatin Anti-Mitotics. Plos One, 11, 2016
5ITZ	Crystal structure of the SAC domain of CPAP in a complex with Tubulin and Darpin 分子名称: Centromere protein J, Designed ankyrin repeat protein (DARPIN) D1, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Sharma, A, Steinmetz, M.O. 登録日 2016-03-17 公開日 2016-06-01 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Centriolar CPAP/SAS-4 Imparts Slow Processive Microtubule Growth. Dev.Cell, 37, 2016
5IJ9	Cryo EM density of microtubule assembled from human TUBB3-D417H mutant 分子名称: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Ti, S.C, Pamula, M.C, Howes, S.C, Duellberg, C, Cade, N.I, Kleiner, R.E, Forth, S, Surrey, T, Nogales, E, Kapoor, T.M. 登録日 2016-03-01 公開日 2016-04-20 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Mutations in Human Tubulin Proximal to the Kinesin-Binding Site Alter Dynamic Instability at Microtubule Plus- and Minus-Ends. Dev.Cell, 37, 2016
5IJ0	Cryo EM density of microtubule assembled from human TUBB3 分子名称: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Ti, S.-C, Pamula, M.C, Howes, S.C, Duellberg, C, Nicholas, C.I, Kleiner, R.E, Forth, S, Surrey, T, Nogales, E, Kapoor, T.M. 登録日 2016-03-01 公開日 2016-04-20 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Mutations in Human Tubulin Proximal to the Kinesin-Binding Site Alter Dynamic Instability at Microtubule Plus- and Minus-Ends. Dev.Cell, 37, 2016
5HNZ	Structural basis of backwards motion in kinesin-14: plus-end directed nKn669 in the nucleotide-free state 分子名称: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Shigematsu, H, Yokoyama, T, Kikkawa, M, Shirouzu, M, Nitta, R. 登録日 2016-01-19 公開日 2016-08-10 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (5.8 Å) 主引用文献 Structural Basis of Backwards Motion in Kinesin-1-Kinesin-14 Chimera: Implication for Kinesin-14 Motility Structure, 24, 2016
5HNY	Structural basis of backwards motion in kinesin-14: plus-end directed nKn669 in the AMPPNP state 分子名称: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Shigematsu, H, Yokoyama, T, Kikkawa, M, Shirouzu, M, Nitta, R. 登録日 2016-01-19 公開日 2016-08-10 最終更新日 2016-11-02 実験手法 ELECTRON MICROSCOPY (6.3 Å) 主引用文献 Structural Basis of Backwards Motion in Kinesin-1-Kinesin-14 Chimera: Implication for Kinesin-14 Motility Structure, 24, 2016
5HNX	Structural basis of backwards motion in kinesin-14: minus-end directed nKn664 in the nucleotide-free state 分子名称: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Shigematsu, H, Yokoyama, T, Kikkawa, M, Shirouzu, M, Nitta, R. 登録日 2016-01-19 公開日 2016-08-10 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (6.6 Å) 主引用文献 Structural Basis of Backwards Motion in Kinesin-1-Kinesin-14 Chimera: Implication for Kinesin-14 Motility Structure, 24, 2016
5HNW	Structural basis of backwards motion in kinesin-14: minus-end directed nKn664 in the AMPPNP state 分子名称: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Shigematsu, H, Yokoyama, T, Kikkawa, M, Shirouzu, M, Nitta, R. 登録日 2016-01-19 公開日 2016-08-10 最終更新日 2018-07-25 実験手法 ELECTRON MICROSCOPY (6.6 Å) 主引用文献 Structural Basis of Backwards Motion in Kinesin-1-Kinesin-14 Chimera: Implication for Kinesin-14 Motility Structure, 24, 2016
5H7O	Crystal structure of DJ-101 in complex with tubulin protein 分子名称: 2-(1H-indol-4-yl)-4-(3,4,5-trimethoxyphenyl)-1H-imidazo[4,5-c]pyridine, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... 著者 Arnst, K, Wang, Y, Hwang, D.-J, Xue, Y, Costello, T, Hamilton, D, Chen, Q, Yang, J, Park, F, Dalton, J.T, Miller, D.D, Li, W. 登録日 2016-11-20 公開日 2017-12-13 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 A Potent, Metabolically Stable Tubulin Inhibitor Targets the Colchicine Binding Site and Overcomes Taxane Resistance. Cancer Res., 78, 2018
5H74	Crystal structure of T2R-TTL-14b complex 分子名称: (2~{S},4~{R})-4-[[2-[(1~{R},3~{R})-1-acetyloxy-3-[hexyl-[(2~{S},3~{S})-3-methyl-2-[[(2~{R})-1-methylpiperidin-2-yl]carbonylamino]pentanoyl]amino]-4-methyl-pentyl]-1,3-thiazol-4-yl]carbonylamino]-5-(4-fluorophenyl)-2-methyl-pentanoic acid, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... 著者 Wang, Y, Yu, Y, Chen, Q, Yang, J. 登録日 2016-11-17 公開日 2017-11-22 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structure-Activity Relationship Studies of Tubulysin Analogues: Anticancer N-Alkyltubulysins with Subpicomolar Activity and the Crystal Structure Binding to Tubulin To Be Published
5H5I	Staphylococcus aureus FtsZ-GDP R29A mutant in R state 分子名称: Cell division protein FtsZ, GUANOSINE-5'-DIPHOSPHATE 著者 Fujita, J, Harada, R, Maeda, Y, Saito, Y, Mizohata, E, Inoue, T, Shigeta, Y, Matsumura, H. 登録日 2016-11-05 公開日 2017-05-24 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Identification of the key interactions in structural transition pathway of FtsZ from Staphylococcus aureus J. Struct. Biol., 198, 2017
5H5H	Staphylococcus aureus FtsZ-GDP R29A mutant in T state 分子名称: CALCIUM ION, Cell division protein FtsZ, GUANOSINE-5'-DIPHOSPHATE 著者 Fujita, J, Harada, R, Maeda, Y, Saito, Y, Mizohata, E, Inoue, T, Shigeta, Y, Matsumura, H. 登録日 2016-11-05 公開日 2017-05-24 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Identification of the key interactions in structural transition pathway of FtsZ from Staphylococcus aureus J. Struct. Biol., 198, 2017

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