5LP6

Crystal structure of Tubulin-Stathmin-TTL-Thiocolchicine Complex

Summary for 5LP6

Entry DOI	10.2210/pdb5lp6/pdb
Descriptor	Tubulin alpha-1B chain, ~{N}-[(7~{R})-1,2,3-trimethoxy-10-methylsulfanyl-9-oxidanylidene-6,7-dihydro-5~{H}-benzo[a]heptalen-7-yl]ethanamide, CALCIUM ION, ... (12 entities in total)
Functional Keywords	microtubules, thiocolchicine, tubulin, tubulin-tyrosine ligase, structural protein
Biological source	Rattus norvegicus (Rat) More
Total number of polymer chains	6
Total formula weight	261968.55
Authors	Marangon, J.,Christodoulou, M.,Casagrande, F.,Tiana, G.,Dalla Via, L.,Aliverti, A.,Passarella, D.,Cappelletti, G.,Ricagno, S. (deposition date: 2016-08-11, release date: 2016-09-21, Last modification date: 2024-01-10)
Primary citation	Marangon, J.,Christodoulou, M.S.,Casagrande, F.V.,Tiana, G.,Dalla Via, L.,Aliverti, A.,Passarella, D.,Cappelletti, G.,Ricagno, S. Tools for the rational design of bivalent microtubule-targeting drugs. Biochem. Biophys. Res. Commun., 479:48-53, 2016 Cited by PubMed: 27613098 DOI: 10.1016/j.bbrc.2016.09.022 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation