5IYZ
Tubulin-MMAE complex
Summary for 5IYZ
Entry DOI | 10.2210/pdb5iyz/pdb |
Related PRD ID | PRD_002173 |
Descriptor | Tubulin alpha-1B chain, N-methyl-L-valyl-N-[(3R,4S,5S)-1-{(2S)-2-[(1R,2R)-3-{[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino}-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl}-3-methoxy-5-methyl-1-oxoheptan-4-yl]-N-methyl-L-valinamide, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (12 entities in total) |
Functional Keywords | cell cycle, cytoskeleton, tubulin fold, microtubule |
Biological source | Rattus norvegicus (Norway Rat) More |
Cellular location | Cytoplasm, cytoskeleton: P81947 Q6B856 Golgi apparatus : P63043 |
Total number of polymer chains | 6 |
Total formula weight | 265902.17 |
Authors | Waight, A.B.,Bargsten, K.,Doronina, S.,Steinmetz, M.O.,Sussman, D.,Prota, A.E. (deposition date: 2016-03-24, release date: 2016-08-17, Last modification date: 2024-01-10) |
Primary citation | Waight, A.B.,Bargsten, K.,Doronina, S.,Steinmetz, M.O.,Sussman, D.,Prota, A.E. Structural Basis of Microtubule Destabilization by Potent Auristatin Anti-Mitotics. Plos One, 11:e0160890-e0160890, 2016 Cited by PubMed: 27518442DOI: 10.1371/journal.pone.0160890 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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