5IYZ

Tubulin-MMAE complex

Summary for 5IYZ

• Entry DOI: 10.2210/pdb5iyz/pdb
• Related PRD ID: PRD_002173
• Descriptor: Tubulin alpha-1B chain, N-methyl-L-valyl-N-[(3R,4S,5S)-1-{(2S)-2-[(1R,2R)-3-{[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino}-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl}-3-methoxy-5-methyl-1-oxoheptan-4-yl]-N-methyl-L-valinamide, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (12 entities in total)
• Functional Keywords: cell cycle, cytoskeleton, tubulin fold, microtubule
• Biological source: Rattus norvegicus (Norway Rat); More
• Cellular location: Cytoplasm, cytoskeleton: P81947 Q6B856; Golgi apparatus : P63043
• Total number of polymer chains: 6
• Total formula weight: 265902.17

Authors

Waight, A.B.,Bargsten, K.,Doronina, S.,Steinmetz, M.O.,Sussman, D.,Prota, A.E. (deposition date: 2016-03-24, release date: 2016-08-17, Last modification date: 2024-01-10)

• Primary citation: Waight, A.B.,Bargsten, K.,Doronina, S.,Steinmetz, M.O.,Sussman, D.,Prota, A.E.; Structural Basis of Microtubule Destabilization by Potent Auristatin Anti-Mitotics.; Plos One, 11:e0160890-e0160890, 2016; PubMed: 27518442; DOI: 10.1371/journal.pone.0160890

Experimental method

X-RAY DIFFRACTION (1.8 Å)