5H7O

Crystal structure of DJ-101 in complex with tubulin protein

Summary for 5H7O

Entry DOI	10.2210/pdb5h7o/pdb
Descriptor	Tubulin alpha-1B chain, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-(1H-indol-4-yl)-4-(3,4,5-trimethoxyphenyl)-1H-imidazo[4,5-c]pyridine, ... (13 entities in total)
Functional Keywords	dj-101, colchicine site tubulin inhibitor, tubulin, taxane resistance, structural protein
Biological source	Sus scrofa (Pig) More
Total number of polymer chains	6
Total formula weight	265088.49
Authors	Arnst, K.,Wang, Y.,Hwang, D.-J.,Xue, Y.,Costello, T.,Hamilton, D.,Chen, Q.,Yang, J.,Park, F.,Dalton, J.T.,Miller, D.D.,Li, W. (deposition date: 2016-11-20, release date: 2017-12-13, Last modification date: 2024-05-22)
Primary citation	Arnst, K.E.,Wang, Y.,Hwang, D.J.,Xue, Y.,Costello, T.,Hamilton, D.,Chen, Q.,Yang, J.,Park, F.,Dalton, J.T.,Miller, D.D.,Li, W. A Potent, Metabolically Stable Tubulin Inhibitor Targets the Colchicine Binding Site and Overcomes Taxane Resistance. Cancer Res., 78:265-277, 2018 Cited by PubMed: 29180476 DOI: 10.1158/0008-5472.CAN-17-0577 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation