5H7O
Crystal structure of DJ-101 in complex with tubulin protein
Summary for 5H7O
Entry DOI | 10.2210/pdb5h7o/pdb |
Descriptor | Tubulin alpha-1B chain, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-(1H-indol-4-yl)-4-(3,4,5-trimethoxyphenyl)-1H-imidazo[4,5-c]pyridine, ... (13 entities in total) |
Functional Keywords | dj-101, colchicine site tubulin inhibitor, tubulin, taxane resistance, structural protein |
Biological source | Sus scrofa (Pig) More |
Total number of polymer chains | 6 |
Total formula weight | 265088.49 |
Authors | Arnst, K.,Wang, Y.,Hwang, D.-J.,Xue, Y.,Costello, T.,Hamilton, D.,Chen, Q.,Yang, J.,Park, F.,Dalton, J.T.,Miller, D.D.,Li, W. (deposition date: 2016-11-20, release date: 2017-12-13, Last modification date: 2024-05-22) |
Primary citation | Arnst, K.E.,Wang, Y.,Hwang, D.J.,Xue, Y.,Costello, T.,Hamilton, D.,Chen, Q.,Yang, J.,Park, F.,Dalton, J.T.,Miller, D.D.,Li, W. A Potent, Metabolically Stable Tubulin Inhibitor Targets the Colchicine Binding Site and Overcomes Taxane Resistance. Cancer Res., 78:265-277, 2018 Cited by PubMed: 29180476DOI: 10.1158/0008-5472.CAN-17-0577 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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