5JCB

Microtubule depolymerizing agent podophyllotoxin derivative YJTSF1

Summary for 5JCB

• Entry DOI: 10.2210/pdb5jcb/pdb
• Descriptor: Tubulin alpha-1B chain, GUANOSINE-5'-DIPHOSPHATE, SODIUM ION, ... (16 entities in total)
• Functional Keywords: microtubule destabilization, podophyllum, structural protein
• Biological source: Gallus gallus (chicken); More
• Cellular location: Cytoplasm, cytoskeleton: Q2XVP4 F2Z5B2
• Total number of polymer chains: 6
• Total formula weight: 268271.69

Authors

Guan, Z.,Zhao, W.,Yin, P. (deposition date: 2016-04-14, release date: 2017-09-27, Last modification date: 2023-11-08)

• Primary citation: Zhao, W.,Zhou, C.,Guan, Z.Y.,Yin, P.,Chen, F.,Tang, Y.J.; Structural Insights into the Inhibition of Tubulin by the Antitumor Agent 4 beta-(1,2,4-triazol-3-ylthio)-4-deoxypodophyllotoxin.; ACS Chem. Biol., 12:746-752, 2017; PubMed: 28035796; DOI: 10.1021/acschembio.6b00842

Experimental method

X-RAY DIFFRACTION (2.3 Å)