5JCB
Microtubule depolymerizing agent podophyllotoxin derivative YJTSF1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C | Tubulin alpha-1B chain | polymer | 451 | 50204.4 | 2 | UniProt (Q2XVP4) Pfam (PF00091) Pfam (PF03953) In PDB | Sus scrofa (Pig) | Alpha-tubulin ubiquitous,Tubulin K-alpha-1,Tubulin alpha-ubiquitous chain |
| 2 | B, D | Tubulin beta chain | polymer | 445 | 49999.9 | 2 | UniProt (F2Z5B2) Pfam (PF00091) Pfam (PF03953) UniProt (by SIFTS) (P02554) In PDB | Sus scrofa (Pig) | |
| 3 | E | Stathmin | polymer | 152 | 18060.4 | 1 | UniProt (F2Z508) Pfam (PF00836) In PDB | Sus scrofa (Pig) | |
| 4 | F | Tubulin-Tyrosine Ligase | polymer | 388 | 44897.1 | 1 | Gallus gallus (chicken) | ||
| 5 | A, C | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 2 | Chemie (GTP) | |||
| 6 | D, A, F, B, C | MAGNESIUM ION | non-polymer | 24.3 | 7 | Chemie (MG) | |||
| 7 | C, D, A | GLYCEROL | non-polymer | 92.1 | 8 | Chemie (GOL) | |||
| 8 | A, C | IMIDAZOLE | non-polymer | 69.1 | 2 | Chemie (IMD) | |||
| 9 | A, C | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
| 10 | D, B | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 2 | Chemie (GDP) | |||
| 11 | B, C | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 12 | B | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 1 | Chemie (MES) | |||
| 13 | D, B | (5R,5aR,8aS,9R)-9-[(4H-1,2,4-triazol-3-yl)sulfanyl]-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tetrahydro-2H-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one | non-polymer | 497.5 | 2 | Chemie (NV4) | |||
| 14 | C | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 15 | F | PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER | non-polymer | 505.2 | 1 | Chemie (ACP) | |||
| 16 | water | water | 18.0 | 557 | Chemie (HOH) |
Sequence modifications
E: 5 - 145 (UniProt: F2Z508)
| PDB | External Database | Details |
|---|---|---|
| Ala 4 | - | expression tag |
| Leu 146 | - | expression tag |
| Glu 147 | - | expression tag |
| His 148 | - | expression tag |
| His 149 | - | expression tag |
| His 150 | - | expression tag |
| His 151 | - | expression tag |
| His 152 | - | expression tag |
| His 153 | - | expression tag |
| His 154 | - | expression tag |
| His 155 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 263366.1 | |
| Non-Polymers* | Number of molecules | 30 |
| Total formula weight | 4905.6 | |
| All* | Total formula weight | 268271.7 |
