PDB: 9935 件ウェブページステータス検索Chemie searchBIRD

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6OC8	Crystal structure of a VHH against the capsid protein from BLV 分子名称: GLYCEROL, SULFATE ION, VHH8c 著者 Carrion, F, Larrieux, N, Trajtenberg, F, Buschiazzo, A. 登録日 2019-03-22 公開日 2020-03-25 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.109 Å) 主引用文献 BLV capsid self-assembly inhibition by heavy chain antibodies To be Published
8B50	Crystal structure of a Fab fragment in complex with L-hydroxycoumarylalanine 分子名称: (2~{S})-2-azanyl-3-(7-oxidanyl-2-oxidanylidene-chromen-4-yl)propanoic acid, Fab fragment K12F9-22 - heavy chain, Fab fragment K12F9-22 - light chain, ... 著者 Meining, W, Eichinger, A, Skerra, A. 登録日 2022-09-21 公開日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.67 Å) 主引用文献 Preparation and characterization of monoclonal antibodies against a non natural amino acid carrying the 7-hydroxycoumarin side chain To be published
6CEZ	Crystal Structure of Rabbit Anti-HIV-1 gp120 V2 Fab 16C2 in complex with V2 peptide ConB 分子名称: HIV-1 gp120 V2 Peptide Con B, Heavy chain of Fab fragment of rabbit anti-HIV1 gp120 V2 mAb 16C2, Light chain of Fab fragment of rabbit anti-HIV1 gp120 V2 mAb 16C2 著者 Kong, X, Pan, R. 登録日 2018-02-13 公開日 2018-09-12 最終更新日 2019-12-18 実験手法 X-RAY DIFFRACTION (2.399 Å) 主引用文献 Select gp120 V2 domain specific antibodies derived from HIV and SIV infection and vaccination inhibit gp120 binding to alpha 4 beta 7. PLoS Pathog., 14, 2018
8TRV	Structure of the EphA2 LBDCRD bound to FabS1C_C1 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Ephrin type-A receptor 2, ... 著者 Singer, A.U, Bruce, H.A, Blazer, L, Adams, J.J, Sicheri, F, Sidhu, S.S. 登録日 2023-08-10 公開日 2024-07-17 実験手法 X-RAY DIFFRACTION (3.25 Å) 主引用文献 Synthetic Antibodies targeting EPHA2 Induce Diverse Signaling-Competent Clusters with Differential Activation To be Published
8TQ1	HIV-1 BG505 Env SOSIP in complex with bovine Fab Bess4 and non-human primate Fab RM20A3 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Bovine Bess4 Fab heavy chain, ... 著者 Ozorowski, G, Lee, W.H, Ward, A.B. 登録日 2023-08-06 公開日 2024-08-07 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Immunization of cows with HIV Envelope trimers generates broadly neutralizing antibodies to the V2-apex as well as the CD4 binding site from the ultra-long CDRH3 repertoire To Be Published
8TV1	Structure of the EphA2 LBDCRD bound to FabS1C_L1 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Ephrin type-A receptor 2, ... 著者 Singer, A.U, Bruce, H.A, Blazer, L, Adams, J.J, Sicheri, F, Sidhu, S.S. 登録日 2023-08-17 公開日 2024-06-26 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Synthetic Antibodies targeting EPHA2 Induce Diverse Signaling-Competent Clusters with Differential Activation To be published
8SUO	BA.2/AZD1061/AZD3152 structure analysis 分子名称: AZD1061 heavy chain, AZD1061 light chain, AZD3152 heavy chain, ... 著者 Oganesyan, V, van Dyk, N, Dippel, A, Barnes, A, O'Connor, E. 登録日 2023-05-12 公開日 2024-05-15 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 X-ray crystal structure of BA.2 RBD bound by two neutralizing antibodies To Be Published
6VRY	Structure of NCI09 fab in complex with SIV V2 peptide 分子名称: NCI09 heavy chain, NCI09 light chain, SIV V2 peptide, ... 著者 Gorman, J, Ahmadi, M, Kwong, P.D. 登録日 2020-02-10 公開日 2020-12-30 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 HIV vaccine candidate with V1 deletion reveals virus vulnerability to V2 antibodies Iscience, 2020
8TV2	Structure of apo FabS1C_L1 分子名称: CHLORIDE ION, S1C variant of Fab_L1 heavy chain, S1C variant of Fab_L1 light chain, ... 著者 Singer, A.U, Bruce, H.A, Blazer, L, Adams, J.J, Sicheri, F, Sidhu, S.S. 登録日 2023-08-17 公開日 2024-07-31 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Synthetic Antibodies targeting EPHA2 Induce Diverse Signaling-Competent Clusters with Differential Activation To be published
7WP6	Cryo-EM structure of SARS-CoV-2 recombinant spike protein STFK in complex with three neutralizing antibodies 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 36H6 heavy chain, ... 著者 Zheng, Q, Sun, H, Yuan, Q, Li, S, Xia, N. 登録日 2022-01-23 公開日 2023-03-01 最終更新日 2023-09-13 実験手法 ELECTRON MICROSCOPY (3.81 Å) 主引用文献 Lineage-mosaic and mutation-patched spike proteins for broad-spectrum COVID-19 vaccine. Cell Host Microbe, 30, 2022
7WP8	Cryo-EM structure of SARS-CoV-2 recombinant spike protein STFK1628x in complex with three neutralizing antibodies 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2B4 heavy chain, ... 著者 Zheng, Q, Sun, H, Yuan, Q, Li, S, Xia, N. 登録日 2022-01-23 公開日 2023-03-08 最終更新日 2023-09-13 実験手法 ELECTRON MICROSCOPY (3.88 Å) 主引用文献 Lineage-mosaic and mutation-patched spike proteins for broad-spectrum COVID-19 vaccine. Cell Host Microbe, 30, 2022
7TDM	CryoEM Structure of sFab COP-2 Complex with human claudin-4 and Clostridium perfringens enterotoxin C-terminal domain 分子名称: COP-2 Fab Heavy chain, COP-2 Fab Light chain, Claudin-4, ... 著者 Vecchio, A.J. 登録日 2022-01-01 公開日 2022-02-09 最終更新日 2024-01-17 実験手法 ELECTRON MICROSCOPY (6.9 Å) 主引用文献 Development, structure, and mechanism of synthetic antibodies that target claudin and Clostridium perfringens enterotoxin complexes. J.Biol.Chem., 298, 2022
7TDN	CryoEM Structure of sFab COP-3 Complex with human claudin-4 and Clostridium perfringens enterotoxin C-terminal domain 分子名称: COP-3 Fab Heavy chain, COP-3 Fab Light chain, Claudin-4, ... 著者 Vecchio, A.J. 登録日 2022-01-01 公開日 2022-02-09 最終更新日 2024-01-17 実験手法 ELECTRON MICROSCOPY (5 Å) 主引用文献 Development, structure, and mechanism of synthetic antibodies that target claudin and Clostridium perfringens enterotoxin complexes. J.Biol.Chem., 298, 2022
7LF5	Structure of Hyperglycosylated Human IgG1 Fc (Fc267) 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, IgG1 Fc (Fc267), alpha-L-fucopyranose, ... 著者 Fields, J.K, Sundberg, E.J. 登録日 2021-01-15 公開日 2021-01-27 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Silent Antibodies: Generation of Hyperglycosylated FCs to Ablate Effector Functions To Be Published
7LBL	Structure of Human IgG1 Fc 分子名称: Ig gamma-1 chain C region, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose 著者 Fields, J.K, Sundberg, E.J. 登録日 2021-01-08 公開日 2021-01-20 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.13 Å) 主引用文献 Silent Antibodies: Generation of Hyperglycosylated FCs to Ablate Effector Functions To Be Published
7LFN	Structure of Hyperglycosylated Human IgG1 Fc (Fc267_329) 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, IgG1 Fc (Fc267_329), alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Fields, J.K, Sundberg, E.J. 登録日 2021-01-17 公開日 2021-01-27 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Silent Antibodies: Generation of Hyperglycosylated FCs to Ablate Effector Functions To Be Published
7LF9	Structure of Hyperglycosylated Human IgG1 Fc (Fc329) 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, IgG1 Fc (Fc329), ... 著者 Fields, J.K, Sundberg, E.J. 登録日 2021-01-15 公開日 2021-01-27 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Silent Antibodies: Generation of Hyperglycosylated FCs to Ablate Effector Functions To Be Published
4TVP	Crystal Structure of the HIV-1 BG505 SOSIP.664 Env Trimer Ectodomain, Comprising Atomic-Level Definition of Pre-Fusion gp120 and gp41, in Complex with Human Antibodies PGT122 and 35O22 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 35O22 Heavy chain, ... 著者 Pancera, M, Zhou, T, Kwong, P.D. 登録日 2014-06-27 公開日 2014-10-08 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Structure and immune recognition of trimeric pre-fusion HIV-1 Env. Nature, 514, 2014
4O9H	Structure of Interleukin-6 in complex with a Camelid Fab fragment 分子名称: Heavy Chain of the Camelid Fab fragment 61H7, Interleukin-6, Light Chain of the Camelid Fab fragment 61H7 著者 Klarenbeek, A, Blanchetot, C, Schragel, G, Sadi, A.S, Ongenae, N, Hemrika, W, Wijdenes, J, Spinelli, S, Desmyter, A, Cambillau, C, Hultberg, A, Kretz-rommel, A, Dreier, T, De haard, H.J.W, Roovers, R.C. 登録日 2014-01-02 公開日 2015-04-15 最終更新日 2015-04-29 実験手法 X-RAY DIFFRACTION (2.42 Å) 主引用文献 Combining residues of naturally-occurring Camelid somatic affinity variants yields ultra-potent human therapeutic IL-6 antibodies To be Published
9BIW	Crystal structure of Chelona Toxin, a diphtheria toxin homolog, from Austwickia chelonae 分子名称: CALCIUM ION, Chelona Toxin 著者 Gill, S.K, Sugiman-Marangos, S.N, Melnyk, R.A. 登録日 2024-04-24 公開日 2024-08-07 実験手法 X-RAY DIFFRACTION (2.496 Å) 主引用文献 A diphtheria toxin-like intracellular delivery platform that evades pre-existing antidrug antibodies Embo Mol Med
9BON	Crystal structure of glucosyltransferase (GTD) domain of TpeL 分子名称: TpeL 著者 Gill, S, Sugiman-Marangos, S.N, Beilhartz, G.L, Mei, E, Taipale, M, Melnyk, R.A. 登録日 2024-05-05 公開日 2024-08-07 実験手法 X-RAY DIFFRACTION (2.222 Å) 主引用文献 A diphtheria toxin-like intracellular delivery platform that evades pre-existing antidrug antibodies. Embo Mol Med, 2024
3CSP	Crystal structure of the DM2 mutant of myelin oligodendrocyte glycoprotein 分子名称: Myelin-oligodendrocyte glycoprotein 著者 Breithaupt, C, Schafer, B, Pellkofer, H, Huber, R, Linington, C, Jacob, U. 登録日 2008-04-10 公開日 2008-10-21 最終更新日 2021-10-20 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Demyelinating myelin oligodendrocyte glycoprotein-specific autoantibody response is focused on one dominant conformational epitope region in rodents J.Immunol., 181, 2008
6WYR	Crystal structure of anti-Muscle Specific Kinase (MuSK) Fab, MuSK1A 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, MuSK1A heavy chain, ... 著者 Vieni, C, Ekiert, D. 登録日 2020-05-13 公開日 2020-07-29 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Affinity maturation is required for pathogenic monovalent IgG4 autoantibody development in myasthenia gravis. J.Exp.Med., 217, 2020
6WYT	Crystal structure of anti-Muscle Specific Kinase (MuSK) Fab, MuSK1B 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, MuSK1B heavy chain, ... 著者 Vieni, C, Ekiert, D. 登録日 2020-05-13 公開日 2020-07-29 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Affinity maturation is required for pathogenic monovalent IgG4 autoantibody development in myasthenia gravis. J.Exp.Med., 217, 2020
5TLJ	COMPLEX BETWEEN HUMAN CD27 AND FAB FRAGMENTS OF ANTIBODIES M2177 AND M2191 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CD27 antigen, M2177 HEAVY CHAIN, ... 著者 Teplyakov, A, Obmolova, G, Malia, T, Gilliland, G.L. 登録日 2016-10-11 公開日 2017-02-08 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Epitope-dependent mechanisms of CD27 neutralization revealed by X-ray crystallography. Mol. Immunol., 83, 2017

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