4O9H

Structure of Interleukin-6 in complex with a Camelid Fab fragment

Summary for 4O9H

• Entry DOI: 10.2210/pdb4o9h/pdb
• Descriptor: Interleukin-6, Heavy Chain of the Camelid Fab fragment 61H7, Light Chain of the Camelid Fab fragment 61H7, ... (4 entities in total)
• Functional Keywords: il6: all alpha protein, fab: all beta protein, immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: P05231
• Total number of polymer chains: 3
• Total formula weight: 67171.20

Authors

Klarenbeek, A.,Blanchetot, C.,Schragel, G.,Sadi, A.S.,Ongenae, N.,Hemrika, W.,Wijdenes, J.,Spinelli, S.,Desmyter, A.,Cambillau, C.,Hultberg, A.,Kretz-rommel, A.,Dreier, T.,De haard, H.J.W.,Roovers, R.C. (deposition date: 2014-01-02, release date: 2015-04-15, Last modification date: 2015-04-29)

• Primary citation: Klarenbeek, A.,Blanchetot, C.,Schragel, G.,Sadi, A.S.,Ongenae, N.,Hemrika, W.,Wijdenes, J.,Spinelli, S.,Desmyter, A.,Cambillau, C.,Hultberg, A.,Kretz-Rommel, A.,Dreier, T.,De haard, H.J.W.,Roovers, R.C.; Combining residues of naturally-occurring Camelid somatic affinity variants yields ultra-potent human therapeutic IL-6 antibodies; To be Published,

Experimental method

X-RAY DIFFRACTION (2.42 Å)