6CEZ

Crystal Structure of Rabbit Anti-HIV-1 gp120 V2 Fab 16C2 in complex with V2 peptide ConB

Summary for 6CEZ

• Entry DOI: 10.2210/pdb6cez/pdb
• Descriptor: Light chain of Fab fragment of rabbit anti-HIV1 gp120 V2 mAb 16C2, Heavy chain of Fab fragment of rabbit anti-HIV1 gp120 V2 mAb 16C2, HIV-1 gp120 V2 Peptide Con B, ... (4 entities in total)
• Functional Keywords: hiv, gp120, v2, antibody, immune system
• Biological source: Oryctolagus cuniculus; More
• Total number of polymer chains: 3
• Total formula weight: 47607.77

Authors

Kong, X.,Pan, R. (deposition date: 2018-02-13, release date: 2018-09-12, Last modification date: 2019-12-18)

• Primary citation: Lertjuthaporn, S.,Cicala, C.,Van Ryk, D.,Liu, M.,Yolitz, J.,Wei, D.,Nawaz, F.,Doyle, A.,Horowitch, B.,Park, C.,Lu, S.,Lou, Y.,Wang, S.,Pan, R.,Jiang, X.,Villinger, F.,Byrareddy, S.N.,Santangelo, P.J.,Morris, L.,Wibmer, C.K.,Biris, K.,Mason, R.D.,Gorman, J.,Hiatt, J.,Martinelli, E.,Roederer, M.,Fujikawa, D.,Gorini, G.,Franchini, G.,Arakelyan, A.,Ansari, A.A.,Pattanapanyasat, K.,Kong, X.P.,Fauci, A.S.,Arthos, J.; Select gp120 V2 domain specific antibodies derived from HIV and SIV infection and vaccination inhibit gp120 binding to alpha 4 beta 7.; PLoS Pathog., 14:e1007278-e1007278, 2018; PubMed: 30153309; DOI: 10.1371/journal.ppat.1007278

Experimental method

X-RAY DIFFRACTION (2.399 Å)