7TDM

CryoEM Structure of sFab COP-2 Complex with human claudin-4 and Clostridium perfringens enterotoxin C-terminal domain

Summary for 7TDM

Entry DOI	10.2210/pdb7tdm/pdb
EMDB information	25834
Descriptor	Claudin-4, Heat-labile enterotoxin B chain, COP-2 Fab Heavy chain, ... (4 entities in total)
Functional Keywords	claudin, cell adhesion, enterotoxin, fab, antibody fragment, membrane protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	85985.21
Authors	Vecchio, A.J. (deposition date: 2022-01-01, release date: 2022-02-09, Last modification date: 2024-01-17)
Primary citation	Orlando, B.J.,Dominik, P.K.,Roy, S.,Ogbu, C.P.,Erramilli, S.K.,Kossiakoff, A.A.,Vecchio, A.J. Development, structure, and mechanism of synthetic antibodies that target claudin and Clostridium perfringens enterotoxin complexes. J.Biol.Chem., 298:102357-102357, 2022 Cited by PubMed: 35952760 DOI: 10.1016/j.jbc.2022.102357 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (6.9 Å)

Structure validation