2B4C
 
 | | Crystal structure of HIV-1 JR-FL gp120 core protein containing the third variable region (V3) complexed with CD4 and the X5 antibody | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, T-cell surface glycoprotein CD4, ... | | 著者 | Huang, C, Tang, M, Zhang, M.Y, Majeed, S, Montabana, E, Stanfield, R.L, Dimitrov, D.S, Korber, B, Sodroski, J, Wilson, I.A, Wyatt, R, Kwong, P.D. | | 登録日 | 2005-09-23 | | 公開日 | 2005-11-15 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Structure of a V3-containing HIV-1 gp120 core.
Science, 310, 2005
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6FXN
 | | Crystal structure of human BAFF in complex with Fab fragment of anti-BAFF antibody belimumab | | 分子名称: | Tumor necrosis factor ligand superfamily member 13B, belimumab heavy chain, belimumab light chain | | 著者 | Lammens, A, Maskos, K, Willen, L, Jiang, X, Schneider, P. | | 登録日 | 2018-03-09 | | 公開日 | 2018-04-04 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | A loop region of BAFF controls B cell survival and regulates recognition by different inhibitors.
Nat Commun, 9, 2018
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4AG4
 | | Crystal structure of a DDR1-Fab complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, EPITHELIAL DISCOIDIN DOMAIN-CONTAINING RECEPTOR 1, ... | | 著者 | Carafoli, F, Mayer, M.C, Shiraishi, K, Pecheva, M.A, Chan, L.Y, Nan, R, Leitinger, B, Hohenester, E. | | 登録日 | 2012-01-24 | | 公開日 | 2012-04-18 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structure of the Discoidin Domain Receptor 1 Extracellular Region Bound to an Inhibitory Fab Fragment Reveals Features Important for Signaling.
Structure, 20, 2012
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1J5O
 | | CRYSTAL STRUCTURE OF MET184ILE MUTANT OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH DOUBLE STRANDED DNA TEMPLATE-PRIMER | | 分子名称: | 5'-D(*AP*TP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*C)-3', 5'-D(*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*GP*CP*GP*CP*CP*A)-3', ANTIBODY (HEAVY CHAIN), ... | | 著者 | Sarafianos, S.G, Das, K, Arnold, E. | | 登録日 | 2002-05-24 | | 公開日 | 2002-06-14 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with beta-branched amino acids.
Proc.Natl.Acad.Sci.USA, 96, 1999
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1YNK
 | | Identification of Key residues of the NC6.8 Fab antibody fragment binding to synthetic sweeteners: Crystal structure of NC6.8 co-crystalized with high potency sweetener compound SC45647 | | 分子名称: | 2-[((R)-{[4-(AMINOMETHYL)PHENYL]AMINO}{[(1R)-1-PHENYLETHYL]AMINO}METHYL)AMINO]ETHANE-1,1-DIOL, Ig gamma heavy chain, immunoglobulin kappa light chain | | 著者 | Gokulan, K, Khare, S, Ronning, D.R, Linthicum, S.D, Sacchettini, J.C, Rupp, B. | | 登録日 | 2005-01-24 | | 公開日 | 2005-08-16 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Cocrystal Structures of NC6.8 Fab Identify Key Interactions for High Potency Sweetener Recognition: Implications for the Design of Synthetic Sweeteners
Biochemistry, 44, 2005
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5GHW
 | | Crystal structure of broad neutralizing antibody 10E8 with long epitope bound | | 分子名称: | Endogenous retrovirus group K member 8 Env polyprotein, FAB 10E8 HEAVY CHAIN, FAB 10E8 LIGHT CHAIN, ... | | 著者 | Caaveiro, J.M.M, Rujas, E, Morante, K, Nieva, J.L, Tsumoto, K. | | 登録日 | 2016-06-21 | | 公開日 | 2016-11-23 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural basis for broad neutralization of HIV-1 through the molecular recognition of 10E8 helical epitope at the membrane interface
Sci Rep, 6, 2016
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8JNK
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8JNR
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6D0X
 | | Crystal structure of chimeric H.2140 / K.1210 Fab in complex with circumsporozoite protein NANP3 | | 分子名称: | 1210 Antibody, light chain, 2140 Antibody, ... | | 著者 | Scally, S.W, Bosch, A, Imkeller, K, Wardemann, H, Julien, J.P. | | 登録日 | 2018-04-11 | | 公開日 | 2018-06-13 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (1.849 Å) | | 主引用文献 | Antihomotypic affinity maturation improves human B cell responses against a repetitive epitope.
Science, 360, 2018
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6D01
 | | Crystal structure of 1210 Fab in complex with circumsporozoite protein NANP5 | | 分子名称: | 1,2-ETHANEDIOL, 1210 Antibody, Light chain, ... | | 著者 | Scally, S.W, Bosch, A, Imkeller, K, Wardemann, H, Julien, J.P. | | 登録日 | 2018-04-09 | | 公開日 | 2018-06-13 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Antihomotypic affinity maturation improves human B cell responses against a repetitive epitope.
Science, 360, 2018
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6D11
 | | Crystal structure of 1450 Fab in complex with circumsporozoite protein NANP5 | | 分子名称: | 1450 Antibody, Heavy chain, Light chain, ... | | 著者 | Scally, S.W, Bosch, A, Imkeller, K, Wardemann, H, Julien, J.P. | | 登録日 | 2018-04-11 | | 公開日 | 2018-06-13 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | Antihomotypic affinity maturation improves human B cell responses against a repetitive epitope.
Science, 360, 2018
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8HLB
 | | Cryo-EM structure of biparatopic antibody Bp109-92 in complex with TNFR2 | | 分子名称: | TR109 heavy chain, TR109 light chain, TR92 heavy chain, ... | | 著者 | Akiba, H, Fujita, J, Ise, T, Nishiyama, K, Miyata, T, Kato, T, Namba, K, Ohno, H, Kamada, H, Nagata, S, Tsumoto, K. | | 登録日 | 2022-11-29 | | 公開日 | 2023-10-04 | | 最終更新日 | 2024-10-16 | | 実験手法 | ELECTRON MICROSCOPY (3.63 Å) | | 主引用文献 | Development of a 1:1-binding biparatopic anti-TNFR2 antagonist by reducing signaling activity through epitope selection.
Commun Biol, 6, 2023
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6FY3
 | | Crystal structure of a V2-directed, RV144 vaccine-like antibody from HIV-1 infection, CAP228-3D, bound to a heterologous V2 peptide | | 分子名称: | CAP228-3D Heavy Chain, CAP228-3D Light Chain, CAP45 V2 peptide | | 著者 | Wibmer, C.K, Moore, P.L, Morris, L. | | 登録日 | 2018-03-10 | | 公開日 | 2018-09-05 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Common helical V1V2 conformations of HIV-1 Envelope expose the alpha 4 beta 7 binding site on intact virions.
Nat Commun, 9, 2018
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6FY2
 | | Crystal structure of a V2p-reactive RV144 vaccine-like antibody, CAP228-16H, in complex with a heterologous CAP225 V1V2 | | 分子名称: | CAP225 Scaffolded V1V2, CAP228-16H Heavy Chain, CAP228-16H Light Chain, ... | | 著者 | Wibmer, C.K, Moore, P.L, Morris, L. | | 登録日 | 2018-03-10 | | 公開日 | 2018-09-05 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2.301 Å) | | 主引用文献 | Common helical V1V2 conformations of HIV-1 Envelope expose the alpha 4 beta 7 binding site on intact virions.
Nat Commun, 9, 2018
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5I66
 | | X-ray structure of the Fab fragment of 8B6, a murine monoclonal antibody specific for the human serotonin transporter | | 分子名称: | 8B6 antibody, heavy chain, light chain | | 著者 | Coleman, J.A, Green, E.M, Gouaux, E. | | 登録日 | 2016-02-16 | | 公開日 | 2016-04-13 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.624 Å) | | 主引用文献 | X-ray structures and mechanism of the human serotonin transporter.
Nature, 532, 2016
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8CDD
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3ZHD
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4QTI
 | | Crystal structure of human uPAR in complex with anti-uPAR Fab 8B12 | | 分子名称: | Urokinase plasminogen activator surface receptor, anti-uPAR antibody, heavy chain, ... | | 著者 | Zhao, B, Yuan, C, Luo, Z, Huang, M. | | 登録日 | 2014-07-08 | | 公開日 | 2015-02-25 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Stabilizing a flexible interdomain hinge region harboring the SMB binding site drives uPAR into its closed conformation.
J.Mol.Biol., 427, 2015
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7A3R
 | | Crystal structure of dengue 1 virus envelope glycoprotein | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Core protein, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose | | 著者 | Sharma, A, Vaney, M.C, Guardado-Calvo, P, Duquerroy, S, Rouvinski, A, Rey, F.A. | | 登録日 | 2020-08-18 | | 公開日 | 2021-12-08 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | | 主引用文献 | The epitope arrangement on flavivirus particles contributes to Mab C10's extraordinary neutralization breadth across Zika and dengue viruses.
Cell, 184, 2021
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3T3M
 | | A Novel High Affinity Integrin alphaIIbbeta3 Receptor Antagonist That Unexpectedly Displaces Mg2+ from the beta3 MIDAS | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | Zhu, J, Zhu, J, Springer, T.A. | | 登録日 | 2011-07-25 | | 公開日 | 2012-03-28 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structure-Guided Design of a High-Affinity Platelet Integrin alphaIIbbeta3 Receptor Antagonist That Disrupts Mg2+ Binding to the MIDAS
Sci Transl Med, 4, 2012
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6MJZ
 | | Cryo-EM structure of Human Parainfluenza Virus Type 3 (hPIV3) in complex with antibody PIA174 | | 分子名称: | Fusion glycoprotein F0, PIA174 Fab Heavy chain, PIA174 Fab Light chain | | 著者 | Acharya, P, Stewart-Jones, G, Carragher, B, Potter, C.S, Kwong, P.D. | | 登録日 | 2018-09-24 | | 公開日 | 2018-11-14 | | 最終更新日 | 2019-12-18 | | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | | 主引用文献 | Structure-based design of a quadrivalent fusion glycoprotein vaccine for human parainfluenza virus types 1-4.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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3SOB
 | | The structure of the first YWTD beta propeller domain of LRP6 in complex with a FAB | | 分子名称: | CALCIUM ION, Low-density lipoprotein receptor-related protein 6, antibody heavy chain, ... | | 著者 | Wang, W, Bourhis, E, Tam, C, Zhang, Y, Rouge, L, Wu, Y, Franke, Y, Cochran, A.G. | | 登録日 | 2011-06-30 | | 公開日 | 2011-09-21 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Wnt antagonists bind through a short peptide to the first beta-propeller domain of LRP5/6.
Structure, 19, 2011
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6RPS
 | | X-ray crystal structure of carbonic anhydrase XII complexed with a theranostic monoclonal antibody fragment | | 分子名称: | ACETATE ION, CADMIUM ION, CHLORIDE ION, ... | | 著者 | Alterio, V, Esposito, D, De Simone, G. | | 登録日 | 2019-05-14 | | 公開日 | 2019-11-13 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.79 Å) | | 主引用文献 | Biochemical and Structural Insights into Carbonic Anhydrase XII/Fab6A10 Complex.
J.Mol.Biol., 431, 2019
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6IAP
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4F37
 | | Structure of the tethered N-terminus of Alzheimer's disease A peptide | | 分子名称: | Colicin-E7 immunity protein, Fab WO2 anti-amyloid-beta antibody Fab fragment, Im7 immunity protein | | 著者 | Nisbet, R.M, Nuttall, S.D, Caine, J.M, Rober, R, Hittaki, M, Pearce, L.A, Davydova, N, Masters, C.L, Varghese, J.N, Streltsov, V.A. | | 登録日 | 2012-05-09 | | 公開日 | 2013-05-15 | | 最終更新日 | 2014-09-03 | | 実験手法 | X-RAY DIFFRACTION (2.57 Å) | | 主引用文献 | Structural studies of the tethered N-terminus of the Alzheimer's disease amyloid-beta peptide.
Proteins, 81, 2013
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