6D0X

Crystal structure of chimeric H.2140 / K.1210 Fab in complex with circumsporozoite protein NANP3

Summary for 6D0X

• Entry DOI: 10.2210/pdb6d0x/pdb
• Related: 6D01
• Descriptor: 2140 Antibody, heavy chain, 1210 Antibody, light chain, NANP3, ... (6 entities in total)
• Functional Keywords: malaria, antibody, circumsporozoite protein, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 49260.71

Authors

Scally, S.W.,Bosch, A.,Imkeller, K.,Wardemann, H.,Julien, J.P. (deposition date: 2018-04-11, release date: 2018-06-13, Last modification date: 2018-07-04)

• Primary citation: Imkeller, K.,Scally, S.W.,Bosch, A.,Marti, G.P.,Costa, G.,Triller, G.,Murugan, R.,Renna, V.,Jumaa, H.,Kremsner, P.G.,Sim, B.K.L.,Hoffman, S.L.,Mordmuller, B.,Levashina, E.A.,Julien, J.P.,Wardemann, H.; Antihomotypic affinity maturation improves human B cell responses against a repetitive epitope.; Science, 360:1358-1362, 2018; PubMed: 29880723; DOI: 10.1126/science.aar5304

Experimental method

X-RAY DIFFRACTION (1.849 Å)