4QTI

Crystal structure of human uPAR in complex with anti-uPAR Fab 8B12

Summary for 4QTI

• Entry DOI: 10.2210/pdb4qti/pdb
• Related: 4QTH
• Descriptor: anti-uPAR antibody, heavy chain, anti-uPAR antibody, light chain, Urokinase plasminogen activator surface receptor (3 entities in total)
• Functional Keywords: allosteric regulation, cell surface, immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Cell membrane . Isoform 1: Cell membrane; Lipid-anchor, GPI- anchor. Isoform 2: Secreted : Q03405
• Total number of polymer chains: 3
• Total formula weight: 79177.14

Authors

Zhao, B.,Yuan, C.,Luo, Z.,Huang, M. (deposition date: 2014-07-08, release date: 2015-02-25, Last modification date: 2023-11-08)

• Primary citation: Zhao, B.,Gandhi, S.,Yuan, C.,Luo, Z.,Li, R.,Gardsvoll, H.,de Lorenzi, V.,Sidenius, N.,Huang, M.,Ploug, M.; Stabilizing a flexible interdomain hinge region harboring the SMB binding site drives uPAR into its closed conformation.; J.Mol.Biol., 427:1389-1403, 2015; PubMed: 25659907; DOI: 10.1016/j.jmb.2015.01.022

Experimental method

X-RAY DIFFRACTION (3 Å)