1J5O

CRYSTAL STRUCTURE OF MET184ILE MUTANT OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH DOUBLE STRANDED DNA TEMPLATE-PRIMER

Replaces:  1C9R
Summary for 1J5O
Related1QE1 2HMI
Descriptor5'-D(*AP*TP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*C)-3', 5'-D(*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*GP*CP*GP*CP*CP*A)-3', Reverse transcriptase, ... (6 entities in total)
Functional Keywordshiv, reverse transcriptase, met184ile, 3tc, protein-dna complex, drug resistance, m184i, transferase-immune system-dna complex, transferase/immune system/dna
Biological sourceHuman immunodeficiency virus 1
More
Cellular locationMatrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03366 P03366
Total number of polymer chains6
Total formula weight172310.89
Authors
Sarafianos, S.G.,Das, K.,Arnold, E. (deposition date: 2002-05-24, release date: 2002-06-14, Last modification date: 2011-07-13)
Primary citationArnold, E.,Boyer, P.L.,Clark Jr., A.D.,Das, K.,Ding, J.,Hughes, S.H.,Sarafianos, S.G.
Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with beta-branched amino acids.
Proc.Natl.Acad.Sci.USA, 96:10027-10032, 1999
PubMed: 10468556
DOI: 110.1073/pnas.96.18.10027
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.5 Å)
Structure validation
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PDB entries from 2021-06-16