1J5O
CRYSTAL STRUCTURE OF MET184ILE MUTANT OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH DOUBLE STRANDED DNA TEMPLATE-PRIMER
Replaces: 1C9RFunctional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0003964 | molecular_function | RNA-directed DNA polymerase activity |
| A | 0004523 | molecular_function | RNA-DNA hybrid ribonuclease activity |
| A | 0006278 | biological_process | RNA-templated DNA biosynthetic process |
| B | 0003964 | molecular_function | RNA-directed DNA polymerase activity |
| B | 0006278 | biological_process | RNA-templated DNA biosynthetic process |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 17 |
| Details | ZN_FING: CCHC-type 1 => ECO:0000255|PROSITE-ProRule:PRU00047 |
| Chain | Residue | Details |
| B | LYS223-THR240 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 17 |
| Details | ZN_FING: CCHC-type 2 => ECO:0000255|PROSITE-ProRule:PRU00047 |
| Chain | Residue | Details |
| B | ILE244-VAL261 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | ACT_SITE: For protease activity; shared with dimeric partner => ECO:0000255|PROSITE-ProRule:PRU10094, ECO:0000269|PubMed:12924029 |
| Chain | Residue | Details |
| B | ARG358 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | SITE: Cis/trans isomerization of proline peptide bond; by human PPIA/CYPA => ECO:0000250 |
| Chain | Residue | Details |
| B | ASN54 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | SITE: Cleavage; by viral protease => ECO:0000250 |
| Chain | Residue | Details |
| B | GLY196 | |
| B | LEU210 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | SITE: Cleavage; by viral protease => ECO:0000255 |
| Chain | Residue | Details |
| B | ASN265 | |
| A | LEU210 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | SITE: Cleavage; by viral protease |
| Chain | Residue | Details |
| B | GLY273 | |
| B | GLY333 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: Asymmetric dimethylarginine; in Nucleocapsid protein p7; by host PRMT6 => ECO:0000269|PubMed:17415034 |
| Chain | Residue | Details |
| B | LYS220 | |
| B | GLN242 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | SITE: Cleavage; by viral protease => ECO:0000269|PubMed:2476069 |
| Chain | Residue | Details |
| A | GLU432 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | MOD_RES: Asymmetric dimethylarginine; in Nucleocapsid protein p7; by host PRMT6 => ECO:0000269|PubMed:17415034 |
| Chain | Residue | Details |
| A | LYS220 | |
| A | GLN242 |
