1QE1
CRYSTAL STRUCTURE OF 3TC-RESISTANT M184I MUTANT OF HIV-1 REVERSE TRANSCRIPTASE
Summary for 1QE1
| Entry DOI | 10.2210/pdb1qe1/pdb |
| Related | 1C9R 1DLO 2HMI |
| Descriptor | REVERSE TRANSCRIPTASE, SUBUNIT P66, REVERSE TRANSCRIPTASE, SUBUNIT P51 (2 entities in total) |
| Functional Keywords | hiv, reverse transcriptase, 3tc, resistance, mutant, dna polymerase, transferase |
| Biological source | Human immunodeficiency virus type 1 BH10 More |
| Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03366 P03366 |
| Total number of polymer chains | 2 |
| Total formula weight | 114149.93 |
| Authors | Sarafianos, S.G.,Das, K.,Ding, J.,Hughes, S.H.,Arnold, E. (deposition date: 1999-07-12, release date: 1999-08-30, Last modification date: 2024-02-14) |
| Primary citation | Sarafianos, S.G.,Das, K.,Clark Jr., A.D.,Ding, J.,Boyer, P.L.,Hughes, S.H.,Arnold, E. Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with beta-branched amino acids. Proc.Natl.Acad.Sci.USA, 96:10027-10033, 1999 Cited by PubMed: 10468556DOI: 10.1073/pnas.96.18.10027 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.85 Å) |
Structure validation
Download full validation report
