Cryo-EM structure of Human Parainfluenza Virus Type 3 (hPIV3) in complex with antibody PIA174

Summary for 6MJZ

EMDB information9135
DescriptorFusion glycoprotein F0, PIA174 Fab Heavy chain, PIA174 Fab Light chain (3 entities in total)
Functional Keywordshpiv3 envelope, asymmetric, complex, antibody, viral protein, viral protein-immune system complex, viral protein/immune system
Biological sourceHuman parainfluenza virus 3
Total number of polymer chains5
Total molecular weight211110.57
Acharya, P.,Stewart-Jones, G.,Carragher, B.,Potter, C.S.,Kwong, P.D. (deposition date: 2018-09-24, release date: 2018-11-14, Last modification date: 2019-12-18)
Primary citation
Stewart-Jones, G.B.E.,Chuang, G.Y.,Xu, K.,Zhou, T.,Acharya, P.,Tsybovsky, Y.,Ou, L.,Zhang, B.,Fernandez-Rodriguez, B.,Gilardi, V.,Silacci-Fregni, C.,Beltramello, M.,Baxa, U.,Druz, A.,Kong, W.P.,Thomas, P.V.,Yang, Y.,Foulds, K.E.,Todd, J.P.,Wei, H.,Salazar, A.M.,Scorpio, D.G.,Carragher, B.,Potter, C.S.,Corti, D.,Mascola, J.R.,Lanzavecchia, A.,Kwong, P.D.
Structure-based design of a quadrivalent fusion glycoprotein vaccine for human parainfluenza virus types 1-4.
Proc. Natl. Acad. Sci. U.S.A., 115:12265-12270, 2018
PubMed: 30420505 (PDB entries with the same primary citation)
DOI: 10.1073/pnas.1811980115
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliers7 0.3% 1.4%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures
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