6MJZ

Cryo-EM structure of Human Parainfluenza Virus Type 3 (hPIV3) in complex with antibody PIA174

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C (A, B, C)	Fusion glycoprotein F0	polymer	495	54970.6	3	UniProt (A0A059QA82) Pfam (PF00523)	Human parainfluenza virus 3
2	D (H)	PIA174 Fab Heavy chain	polymer	221	23512.5	1		Homo sapiens (human)
3	E (L)	PIA174 Fab Light chain	polymer	207	22686.2	1		Homo sapiens (human)

Sequence modifications

A, B, C: 19 - 481 (UniProt: A0A059QA82)

PDB	External Database	Details
Cys 162	Gln 162	engineered mutation
Cys 168	Leu 168	engineered mutation
Cys 213	Ile 213	engineered mutation
Cys 230	Gly 230	engineered mutation
Val 463	Ala 463	engineered mutation
Tyr 474	Ile 474	engineered mutation
Ser 482	-	expression tag
Ala 483	-	expression tag
Ile 484	-	expression tag
Glu 485	-	expression tag
Asp 486	-	expression tag
Lys 487	-	expression tag
Ile 488	-	expression tag
Glu 489	-	expression tag
Glu 490	-	expression tag
Ile 491	-	expression tag
Leu 492	-	expression tag
Ser 493	-	expression tag
Lys 494	-	expression tag
Ile 495	-	expression tag
Tyr 496	-	expression tag
His 497	-	expression tag
Ile 498	-	expression tag
Glu 499	-	expression tag
Asn 500	-	expression tag
Glu 501	-	expression tag
Ile 502	-	expression tag
Ala 503	-	expression tag
Arg 504	-	expression tag
Ile 505	-	expression tag
Lys 506	-	expression tag
Lys 507	-	expression tag
Leu 508	-	expression tag
Ile 509	-	expression tag
Gly 510	-	expression tag
Glu 511	-	expression tag
Ala 512	-	expression tag
Pro 513	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	211110.6
All*	Total formula weight	211110.6

*Water molecules are not included.