6FXN

Crystal structure of human BAFF in complex with Fab fragment of anti-BAFF antibody belimumab

Replaces:  6ERX

Summary for 6FXN

• Entry DOI: 10.2210/pdb6fxn/pdb
• Descriptor: Tumor necrosis factor ligand superfamily member 13B, belimumab heavy chain, belimumab light chain, ... (4 entities in total)
• Functional Keywords: immunology, b cell, cytokine, baff, antibody, proteros, immune system
• Biological source: Homo sapiens (Human); More
• Cellular location: Cell membrane; Single-pass type II membrane protein. Tumor necrosis factor ligand superfamily member 13b, soluble form: Secreted: Q9Y275
• Total number of polymer chains: 18
• Total formula weight: 389186.91

Authors

Lammens, A.,Maskos, K.,Willen, L.,Jiang, X.,Schneider, P. (deposition date: 2018-03-09, release date: 2018-04-04, Last modification date: 2024-01-17)

• Primary citation: Vigolo, M.,Chambers, M.G.,Willen, L.,Chevalley, D.,Maskos, K.,Lammens, A.,Tardivel, A.,Das, D.,Kowalczyk-Quintas, C.,Schuepbach-Mallepell, S.,Smulski, C.R.,Eslami, M.,Rolink, A.,Hummler, E.,Samy, E.,Fomekong Nanfack, Y.,Mackay, F.,Liao, M.,Hess, H.,Jiang, X.,Schneider, P.; A loop region of BAFF controls B cell survival and regulates recognition by different inhibitors.; Nat Commun, 9:1199-1199, 2018; PubMed: 29572442; DOI: 10.1038/s41467-018-03323-8

Experimental method

X-RAY DIFFRACTION (2.9 Å)