6FXN

Crystal structure of human BAFF in complex with Fab fragment of anti-BAFF antibody belimumab

Replaces:  6ERX

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, J, K...	Tumor necrosis factor ligand superfamily member 13B	polymer	164	18394.9	6	UniProt (Q9Y275) Pfam (PF00229) In PDB	Homo sapiens (Human)	B lymphocyte stimulator,BLyS,B-cell-activating factor,BAFF,Dendritic cell-derived TNF-like molecule,TNF- and APOL-related leukocyte expressed ligand 1,TALL-1
2	D, F, H, M, O...	belimumab heavy chain	polymer	225	23704.6	6		Homo sapiens
3	E, G, I, N, P...	belimumab light chain	polymer	214	22764.9	6		Homo sapiens
4		water	water		18.0	270	Chemie (HOH)

Sequence modifications

A, B, C, J, K, L: 134 - 285 (UniProt: Q9Y275)

PDB	External Database	Details
Met 122	-	initiating methionine
Arg 123	-	expression tag
Gly 124	-	expression tag
Ser 125	-	expression tag
His 126	-	expression tag
His 127	-	expression tag
His 128	-	expression tag
His 129	-	expression tag
His 130	-	expression tag
His 131	-	expression tag
Gly 132	-	expression tag
Ser 133	-	expression tag
Ala 218	His 218	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	18
	Total formula weight	389186.9
All*	Total formula weight	389186.9

*Water molecules are not included.