6RPS

X-ray crystal structure of carbonic anhydrase XII complexed with a theranostic monoclonal antibody fragment

Summary for 6RPS

• Entry DOI: 10.2210/pdb6rps/pdb
• Descriptor: Carbonic anhydrase 12, Fab Light chain, Fab Heavy chain, ... (9 entities in total)
• Functional Keywords: anticancer drugs, carbonic anhydrase xii, complex, monoclonal antibody, lyase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 160609.37

Authors

Alterio, V.,Esposito, D.,De Simone, G. (deposition date: 2019-05-14, release date: 2019-11-13, Last modification date: 2024-01-24)

• Primary citation: Alterio, V.,Kellner, M.,Esposito, D.,Liesche-Starnecker, F.,Bua, S.,Supuran, C.T.,Monti, S.M.,Zeidler, R.,De Simone, G.; Biochemical and Structural Insights into Carbonic Anhydrase XII/Fab6A10 Complex.; J.Mol.Biol., 431:4910-4921, 2019; PubMed: 31682835; DOI: 10.1016/j.jmb.2019.10.022

Experimental method

X-RAY DIFFRACTION (2.79 Å)