6RPS

X-ray crystal structure of carbonic anhydrase XII complexed with a theranostic monoclonal antibody fragment

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Carbonic anhydrase 12	polymer	283	31605.0	2	UniProt (O43570) Pfam (PF00194)	Homo sapiens (Human)	Carbonate dehydratase XII,Carbonic anhydrase XII,CA-XII,Tumor antigen HOM-RCC-3.1.3
2	C, E (M, L)	Fab Light chain	polymer	216	23573.1	2		Homo sapiens (Human)
3	D, F (N, H)	Fab Heavy chain	polymer	229	24663.5	2		Homo sapiens (Human)
4	G, N (A, B)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
5	H, O (A, B)	ACETATE ION	non-polymer		59.0	2	Chemie (ACT)
6	I, Q (A, N)	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
7	J, L, M, P (A, B)	CADMIUM ION	non-polymer		112.4	4	Chemie (CD)
8	K (A)	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
9	R, S, T, U, V (A, B, M, N, L)	water	water		18.0	23	Chemie (HOH)

Sequence modifications

A, B: 4 - 262 (UniProt: O43570)

PDB	External Database	Details
Met 3	-	initiating methionine
Gly 263	-	expression tag
Gly 264	-	expression tag
Gly 265	-	expression tag
Gly 266	-	expression tag
Ser 267	-	expression tag
Gly 268	-	expression tag
Gly 269	-	expression tag
Gly 270	-	expression tag
Gly 271	-	expression tag
Ser 272	-	expression tag
Gly 273	-	expression tag
Gly 274	-	expression tag
Gly 275	-	expression tag
Gly 276	-	expression tag
Ser 277	-	expression tag
His 278	-	expression tag
His 279	-	expression tag
His 280	-	expression tag
His 281	-	expression tag
His 282	-	expression tag
His 283	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	159683.2
Non-Polymers*	Number of molecules	11
	Total formula weight	926.1
All*	Total formula weight	160609.4

*Water molecules are not included.