1YNK
Identification of Key residues of the NC6.8 Fab antibody fragment binding to synthetic sweeteners: Crystal structure of NC6.8 co-crystalized with high potency sweetener compound SC45647
Summary for 1YNK
Entry DOI | 10.2210/pdb1ynk/pdb |
Related | 1YNL |
Descriptor | immunoglobulin kappa light chain, Ig gamma heavy chain, 2-[((R)-{[4-(AMINOMETHYL)PHENYL]AMINO}{[(1R)-1-PHENYLETHYL]AMINO}METHYL)AMINO]ETHANE-1,1-DIOL, ... (4 entities in total) |
Functional Keywords | sweetener compound, sc45657 and nc174, immune system |
Biological source | Mus musculus (house mouse) More |
Total number of polymer chains | 2 |
Total formula weight | 47809.25 |
Authors | Gokulan, K.,Khare, S.,Ronning, D.R.,Linthicum, S.D.,Sacchettini, J.C.,Rupp, B. (deposition date: 2005-01-24, release date: 2005-08-16, Last modification date: 2023-08-23) |
Primary citation | Gokulan, K.,Khare, S.,Ronning, D.R.,Linthicum, S.D.,Sacchettini, J.C.,Rupp, B. Cocrystal Structures of NC6.8 Fab Identify Key Interactions for High Potency Sweetener Recognition: Implications for the Design of Synthetic Sweeteners Biochemistry, 44:9889-9898, 2005 Cited by PubMed: 16026161DOI: 10.1021/bi050613u PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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