8HLB

Cryo-EM structure of biparatopic antibody Bp109-92 in complex with TNFR2

Summary for 8HLB

Entry DOI	10.2210/pdb8hlb/pdb
EMDB information	34871
Descriptor	Tumor necrosis factor receptor superfamily member 1B,Maltose/maltodextrin-binding periplasmic protein, TR109 heavy chain, TR109 light chain, ... (5 entities in total)
Functional Keywords	tnfr2, biparatopic antibody, antagonist, immune system
Biological source	Homo sapiens (human) More
Total number of polymer chains	5
Total formula weight	158513.69
Authors	Akiba, H.,Fujita, J.,Ise, T.,Nishiyama, K.,Miyata, T.,Kato, T.,Namba, K.,Ohno, H.,Kamada, H.,Nagata, S.,Tsumoto, K. (deposition date: 2022-11-29, release date: 2023-10-04)
Primary citation	Akiba, H.,Fujita, J.,Ise, T.,Nishiyama, K.,Miyata, T.,Kato, T.,Namba, K.,Ohno, H.,Kamada, H.,Nagata, S.,Tsumoto, K. Development of a 1:1-binding biparatopic anti-TNFR2 antagonist by reducing signaling activity through epitope selection. Commun Biol, 6:987-987, 2023 Cited by PubMed: 37758868 DOI: 10.1038/s42003-023-05326-8 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.63 Å)

Structure validation