8HLB

Cryo-EM structure of biparatopic antibody Bp109-92 in complex with TNFR2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Tumor necrosis factor receptor superfamily member 1B,Maltose/maltodextrin-binding periplasmic protein	polymer	550	60447.3	1	UniProt (P20333) UniProt (P0AEX9) Pfam (PF00020) Pfam (PF01547)	Homo sapiens (human)	Tumor necrosis factor receptor 2,TNF-R2,Tumor necrosis factor receptor type II,TNF-RII,TNFR-II,p75,p80 TNF-alpha receptor,MMBP,Maltodextrin-binding protein,Maltose-binding protein,MBP
2	B (B)	TR109 heavy chain	polymer	236	25080.3	1		Homo sapiens
3	C (C)	TR109 light chain	polymer	218	23852.3	1		Homo sapiens
4	D (D)	TR92 heavy chain	polymer	238	25543.6	1		Homo sapiens
5	E (E)	TR92 light chain	polymer	214	23590.2	1		Homo sapiens

Sequence modifications

A: 1 - 178 (UniProt: P20333)
A: 179 - 543 (UniProt: P0AEX9)

PDB	External Database	Details
Val 490	Ala 338	engineered mutation
Gly 544	-	expression tag
His 545	-	expression tag
His 546	-	expression tag
His 547	-	expression tag
His 548	-	expression tag
His 549	-	expression tag
His 550	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	158513.7
All*	Total formula weight	158513.7

*Water molecules are not included.