8HLB
Cryo-EM structure of biparatopic antibody Bp109-92 in complex with TNFR2
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Tumor necrosis factor receptor superfamily member 1B,Maltose/maltodextrin-binding periplasmic protein | polymer | 550 | 60447.3 | 1 | UniProt (P20333) UniProt (P0AEX9) Pfam (PF00020) Pfam (PF01547) In PDB | Homo sapiens (human) | Tumor necrosis factor receptor 2,TNF-R2,Tumor necrosis factor receptor type II,TNF-RII,TNFR-II,p75,p80 TNF-alpha receptor,MMBP,Maltodextrin-binding protein,Maltose-binding protein,MBP |
2 | B | TR109 heavy chain | polymer | 236 | 25080.3 | 1 | Homo sapiens | ||
3 | C | TR109 light chain | polymer | 218 | 23852.3 | 1 | Homo sapiens | ||
4 | D | TR92 heavy chain | polymer | 238 | 25543.6 | 1 | Homo sapiens | ||
5 | E | TR92 light chain | polymer | 214 | 23590.2 | 1 | Homo sapiens |
Sequence modifications
A: 1 - 178 (UniProt: P20333)
A: 179 - 543 (UniProt: P0AEX9)
A: 179 - 543 (UniProt: P0AEX9)
PDB | External Database | Details |
---|---|---|
Val 490 | Ala 338 | engineered mutation |
Gly 544 | - | expression tag |
His 545 | - | expression tag |
His 546 | - | expression tag |
His 547 | - | expression tag |
His 548 | - | expression tag |
His 549 | - | expression tag |
His 550 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 5 |
Total formula weight | 158513.7 | |
All* | Total formula weight | 158513.7 |