8HLB
Cryo-EM structure of biparatopic antibody Bp109-92 in complex with TNFR2
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005031 | molecular_function | tumor necrosis factor receptor activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0006954 | biological_process | inflammatory response |
| A | 0006974 | biological_process | DNA damage response |
| A | 0008643 | biological_process | carbohydrate transport |
| A | 0015144 | molecular_function | carbohydrate transmembrane transporter activity |
| A | 0015768 | biological_process | maltose transport |
| A | 0016020 | cellular_component | membrane |
| A | 0030288 | cellular_component | outer membrane-bounded periplasmic space |
| A | 0034219 | biological_process | carbohydrate transmembrane transport |
| A | 0034289 | biological_process | detection of maltose stimulus |
| A | 0042597 | cellular_component | periplasmic space |
| A | 0042956 | biological_process | maltodextrin transmembrane transport |
| A | 0043190 | cellular_component | ATP-binding cassette (ABC) transporter complex |
| A | 0055052 | cellular_component | ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0060326 | biological_process | cell chemotaxis |
| A | 1901982 | molecular_function | maltose binding |
| A | 1990060 | cellular_component | maltose transport complex |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH |
| Chain | Residue | Details |
| B | TYR198-HIS204 | |
| D | TYR200-HIS206 | |
| C | TYR196-HIS202 | |
| E | TYR192-HIS198 |
| site_id | PS00652 |
| Number of Residues | 36 |
| Details | TNFR_NGFR_1 TNFR/NGFR family cysteine-rich region signature. Crlrey.Ydqtaqm....C..Csk.Cspgqhakvf..Ctkts..DTVC |
| Chain | Residue | Details |
| A | CYS18-CYS53 | |
| A | CYS56-CYS96 |
| site_id | PS01037 |
| Number of Residues | 18 |
| Details | SBP_BACTERIAL_1 Bacterial extracellular solute-binding proteins, family 1 signature. PIAvEalSLIYNkdlLpN |
| Chain | Residue | Details |
| A | PRO285-ASN302 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | CARBOHYD: O-linked (GalNAc...) threonine => ECO:0000269|PubMed:25456591 |
| Chain | Residue | Details |
| A | THR8 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN149 | |
| A | ASN171 |
