5VL7
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![BU of 5vl7 by Molmil](/molmil-images/mine/5vl7) | PCSK9 complex with Fab33 | 分子名称: | Fab33 heavy chain, Fab33 light chain, Proprotein convertase subtilisin/kexin type 9 | 著者 | Eigenbrot, C, Shia, S. | 登録日 | 2017-04-25 | 公開日 | 2017-08-16 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Discovery of a cryptic peptide-binding site on PCSK9 and design of antagonists. Nat. Struct. Mol. Biol., 24, 2017
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5VL3
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![BU of 5vl3 by Molmil](/molmil-images/mine/5vl3) | CD22 d1-d3 in complex with therapeutic Fab Epratuzumab | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, B-cell receptor CD22, Epratuzumab Fab Heavy Chain, ... | 著者 | Sicard, T, Ereno-Orbea, J, Julien, J.P. | 登録日 | 2017-04-24 | 公開日 | 2017-10-11 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Molecular basis of human CD22 function and therapeutic targeting. Nat Commun, 8, 2017
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5VKK
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5NQK
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![BU of 5nqk by Molmil](/molmil-images/mine/5nqk) | human 199.16 TCR in complex with Melan-A/MART-1 (26-35) peptide and HLA-A2 | 分子名称: | Beta-2-microglobulin, HLA class I histocompatibility antigen, A-2 alpha chain, ... | 著者 | Exertier, C, Reiser, J.-B, Lantez, V, Chouquet, A, Bonneville, M, Saulquin, X, Housset, D. | 登録日 | 2017-04-20 | 公開日 | 2018-05-30 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | 主引用文献 | human 199.16 TCR in complex with Melan-A/MART-1 (26-35) peptide and HLA-A2 To Be Published
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5VJ6
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5VIY
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![BU of 5viy by Molmil](/molmil-images/mine/5viy) | |
5VIG
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![BU of 5vig by Molmil](/molmil-images/mine/5vig) | Crystal structure of anti-Zika antibody Z006 bound to Zika virus envelope protein DIII | 分子名称: | CITRATE ANION, Fab heavy chain, Fab light chain, ... | 著者 | Keeffe, J.R, West Jr, A.P, Gristick, H.B, Bjorkman, P.J. | 登録日 | 2017-04-16 | 公開日 | 2017-05-03 | 最終更新日 | 2017-05-17 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Recurrent Potent Human Neutralizing Antibodies to Zika Virus in Brazil and Mexico. Cell, 169, 2017
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5VIC
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![BU of 5vic by Molmil](/molmil-images/mine/5vic) | Crystal structure of anti-Zika antibody Z004 bound to DENV-1 Envelope protein DIII | 分子名称: | Dengue 1 Envelope DIII domain, Fab heavy chain, Fab light chain | 著者 | Keeffe, J.R, West Jr, A.P, Gristick, H.B, Bjorkman, P.J. | 登録日 | 2017-04-14 | 公開日 | 2017-05-03 | 最終更新日 | 2017-05-17 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Recurrent Potent Human Neutralizing Antibodies to Zika Virus in Brazil and Mexico. Cell, 169, 2017
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5VEB
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![BU of 5veb by Molmil](/molmil-images/mine/5veb) | Crystal structure of a Fab binding to extracellular domain 5 of Cadherin-6 | 分子名称: | 2-acetamido-2-deoxy-alpha-D-galactopyranose, Cadherin-6, anti-CDH6 Fab heavy chain, ... | 著者 | Zhu, X, Bialucha, C.U, London, A, Clark, K, Hu, T. | 登録日 | 2017-04-04 | 公開日 | 2017-06-07 | 最終更新日 | 2024-04-24 | 実験手法 | X-RAY DIFFRACTION (2.34 Å) | 主引用文献 | Discovery and Optimization of HKT288, a Cadherin-6-Targeting ADC for the Treatment of Ovarian and Renal Cancers. Cancer Discov, 7, 2017
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5VCJ
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![BU of 5vcj by Molmil](/molmil-images/mine/5vcj) | Structure of alpha-galactosylphytosphingosine bound by CD1d and in complex with the Va14Vb8.2 TCR | 分子名称: | (2S,3S,4R)-2-amino-3,4-dihydroxyoctadecyl alpha-D-galactopyranoside, 2-acetamido-2-deoxy-beta-D-glucopyranose, Antigen-presenting glycoprotein CD1d1, ... | 著者 | Wang, J, Zajonc, D.M. | 登録日 | 2017-03-31 | 公開日 | 2018-04-04 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.16 Å) | 主引用文献 | Enhancing T cell responses and tumour immunity by vaccination with peptides conjugated to a weak NKT cell agonist. Org. Biomol. Chem., 17, 2019
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5NIU
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![BU of 5niu by Molmil](/molmil-images/mine/5niu) | Structure of human Programmed cell death 1 ligand 1 (PD-L1) with low molecular mass inhibitor | 分子名称: | (2~{R})-2-[[2-[(3-cyanophenyl)methoxy]-4-[[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methyl-phenyl]methoxy]-5-methyl-phenyl]methylamino]-3-oxidanyl-propanoic acid, 1,2-ETHANEDIOL, Programmed cell death 1 ligand 1 | 著者 | Zak, K.M, Grudnik, P, Skalniak, L, Dubin, G, Holak, T.A. | 登録日 | 2017-03-27 | 公開日 | 2017-12-06 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | Small-molecule inhibitors of PD-1/PD-L1 immune checkpoint alleviate the PD-L1-induced exhaustion of T-cells. Oncotarget, 8, 2017
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5NHT
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![BU of 5nht by Molmil](/molmil-images/mine/5nht) | human 199.54-16 TCR in complex with Melan-A/MART-1 (26-35) peptide and HLA-A2 | 分子名称: | Beta-2-microglobulin, CHLORIDE ION, HLA class I histocompatibility antigen, ... | 著者 | Exertier, C, Reiser, J.-B, Lantez, V, Chouquet, A, Bonneville, M, Saulquin, X, Housset, D. | 登録日 | 2017-03-22 | 公開日 | 2018-05-16 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | human 199.54-16 TCR in complex with Melan-A/MART-1 (26-35) peptide and HLA-A2 To Be Published
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5XAX
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5XAW
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![BU of 5xaw by Molmil](/molmil-images/mine/5xaw) | Parallel homodimer structures of voltage-gated sodium channel beta4 for cell-cell adhesion | 分子名称: | 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, GLYCEROL, Sodium channel subunit beta-4, ... | 著者 | Shimizu, H, Yokoyama, S. | 登録日 | 2017-03-15 | 公開日 | 2017-07-05 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.101 Å) | 主引用文献 | Parallel homodimer structures of the extracellular domains of the voltage-gated sodium channel beta 4 subunit explain its role in cell-cell adhesion J. Biol. Chem., 292, 2017
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5V52
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![BU of 5v52 by Molmil](/molmil-images/mine/5v52) | Structure of TIGIT bound to nectin-2 (CD112) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Nectin-2, ... | 著者 | Deuss, F.A, Gully, B.S, Rossjohn, J, Berry, R. | 登録日 | 2017-03-13 | 公開日 | 2017-05-24 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Recognition of nectin-2 by the natural killer cell receptor T cell immunoglobulin and ITIM domain (TIGIT). J. Biol. Chem., 292, 2017
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5X8M
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![BU of 5x8m by Molmil](/molmil-images/mine/5x8m) | PD-L1 in complex with durvalumab | 分子名称: | Programmed cell death 1 ligand 1, durvalumab heavy chain, durvalumab light chain | 著者 | Heo, Y.S, Lee, H.T. | 登録日 | 2017-03-03 | 公開日 | 2017-08-16 | 実験手法 | X-RAY DIFFRACTION (2.661 Å) | 主引用文献 | Molecular mechanism of PD-1/PD-L1 blockade via anti-PD-L1 antibodies atezolizumab and durvalumab Sci Rep, 7, 2017
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5X8L
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![BU of 5x8l by Molmil](/molmil-images/mine/5x8l) | PD-L1 in complex with atezolizumab | 分子名称: | Programmed cell death 1 ligand 1, atezolizumab heavy chain, atezolizumab light chain | 著者 | Heo, Y.S, Lee, H.T. | 登録日 | 2017-03-03 | 公開日 | 2017-08-16 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Molecular mechanism of PD-1/PD-L1 blockade via anti-PD-L1 antibodies atezolizumab and durvalumab Sci Rep, 7, 2017
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5N7B
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![BU of 5n7b by Molmil](/molmil-images/mine/5n7b) | Understanding the singular conformational landscape of the Tn antigens: Sulfur-for- oxygen substitution in the glycosidic linkage provides new insights into molecular recognition by an antibody | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-alpha-D-galactopyranose, APD(CG6)RP(NH2) peptide, ... | 著者 | Companon, I, Martinez-Saez, N, Castro-Lopez, J, Jimenez-Barbero, J, Bernardes, G.J.L, Busto, J.H, Avenoza, A, Jimenez-Oses, G, Hurtado-Guerrero, R, Peregrina, J.M, Corzana, F. | 登録日 | 2017-02-20 | 公開日 | 2018-06-27 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structure-Based Design of Potent Tumor-Associated Antigens: Modulation of Peptide Presentation by Single-Atom O/S or O/Se Substitutions at the Glycosidic Linkage. J.Am.Chem.Soc., 141, 2019
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5X5W
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![BU of 5x5w by Molmil](/molmil-images/mine/5x5w) | Crystal structure of pseudorabies virus glycoprotein D | 分子名称: | GD, Nectin-1 | 著者 | Li, A, Lu, G, Qi, J, Wu, L, Tian, K, Luo, T, Shi, Y, Yan, J, Gao, G.F. | 登録日 | 2017-02-17 | 公開日 | 2017-04-26 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Crystal structure of pseudorabies virus glycoprotein D To Be Published
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5UTZ
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![BU of 5utz by Molmil](/molmil-images/mine/5utz) | Human IL-2/Fab complex | 分子名称: | Fab 5111 heavy chain, Fab 5111 light chain, GLYCEROL, ... | 著者 | Jude, K.M, Garcia, K.C. | 登録日 | 2017-02-15 | 公開日 | 2018-07-11 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.747 Å) | 主引用文献 | A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism. Nat. Med., 24, 2018
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5N2F
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![BU of 5n2f by Molmil](/molmil-images/mine/5n2f) | Structure of PD-L1/small-molecule inhibitor complex | 分子名称: | 4-[[4-[[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methyl-phenyl]methoxy]-2,5-bis(fluoranyl)phenyl]methylamino]-3-oxidanylidene-butanoic acid, Programmed cell death 1 ligand 1 | 著者 | Guzik, K, Zak, K.M, Grudnik, P, Dubin, G, Holak, T.A. | 登録日 | 2017-02-07 | 公開日 | 2017-06-28 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Death-Ligand 1 (PD-1/PD-L1) Interaction via Transiently Induced Protein States and Dimerization of PD-L1. J. Med. Chem., 60, 2017
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5N2D
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![BU of 5n2d by Molmil](/molmil-images/mine/5n2d) | Structure of PD-L1/small-molecule inhibitor complex | 分子名称: | Programmed cell death 1 ligand 1, ~{N}-[2-[[2,6-dimethoxy-4-[(2-methyl-3-phenyl-phenyl)methoxy]phenyl]methylamino]ethyl]ethanamide | 著者 | Guzik, K, Zak, K.M, Grudnik, P, Dubin, G, Holak, T.A. | 登録日 | 2017-02-07 | 公開日 | 2017-06-28 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Death-Ligand 1 (PD-1/PD-L1) Interaction via Transiently Induced Protein States and Dimerization of PD-L1. J. Med. Chem., 60, 2017
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5UKB
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![BU of 5ukb by Molmil](/molmil-images/mine/5ukb) | VSV N PROTEIN IN COMPLEX WITH INHIBITORY NANOBODY 1004 | 分子名称: | Anti-vesicular stomatitis virus N VHH, Nucleocapsid, RNA (45-MER) | 著者 | Hanke, L, Knockenhauer, K.E, Ploegh, H.L, Schwartz, T.U. | 登録日 | 2017-01-20 | 公開日 | 2017-04-19 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (5.473 Å) | 主引用文献 | Vesicular stomatitis virus N protein-specific single-domain antibody fragments inhibit replication. EMBO Rep., 18, 2017
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5UK4
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![BU of 5uk4 by Molmil](/molmil-images/mine/5uk4) | VESICULAR STOMATITS VIRUS N PROTEIN IN COMPLEX WITH INHIBITORY NANOBODY 1307 | 分子名称: | Anti-vesicular stomatitis virus N VHH, Nucleoprotein, RNA (45-MER) | 著者 | Hanke, L, Knockenhauer, K.E, Ploegh, H.L, Schwartz, T.U. | 登録日 | 2017-01-19 | 公開日 | 2017-04-19 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.204 Å) | 主引用文献 | Vesicular stomatitis virus N protein-specific single-domain antibody fragments inhibit replication. EMBO Rep., 18, 2017
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5MTL
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![BU of 5mtl by Molmil](/molmil-images/mine/5mtl) | Crystal structure of an amyloidogenic light chain | 分子名称: | light chain dimer,IGL@ protein,IGL@ protein | 著者 | Oberti, L, Rognoni, P, Russo, R, Bacarizo, J, Bolognesi, M, Ricagno, S. | 登録日 | 2017-01-10 | 公開日 | 2017-12-13 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Concurrent structural and biophysical traits link with immunoglobulin light chains amyloid propensity. Sci Rep, 7, 2017
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