5VL7
PCSK9 complex with Fab33
Summary for 5VL7
Entry DOI | 10.2210/pdb5vl7/pdb |
Descriptor | Proprotein convertase subtilisin/kexin type 9, Fab33 heavy chain, Fab33 light chain, ... (4 entities in total) |
Functional Keywords | immunoglobulin proprotein convertase, subtilisin, hydrolase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 123017.27 |
Authors | Eigenbrot, C.,Shia, S. (deposition date: 2017-04-25, release date: 2017-08-16, Last modification date: 2023-10-04) |
Primary citation | Zhang, Y.,Ultsch, M.,Skelton, N.J.,Burdick, D.J.,Beresini, M.H.,Li, W.,Kong-Beltran, M.,Peterson, A.,Quinn, J.,Chiu, C.,Wu, Y.,Shia, S.,Moran, P.,Di Lello, P.,Eigenbrot, C.,Kirchhofer, D. Discovery of a cryptic peptide-binding site on PCSK9 and design of antagonists. Nat. Struct. Mol. Biol., 24:848-856, 2017 Cited by PubMed: 28825733DOI: 10.1038/nsmb.3453 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.5 Å) |
Structure validation
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