5VL7

PCSK9 complex with Fab33

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Proprotein convertase subtilisin/kexin type 9	polymer	152	17035.5	1	UniProt (Q8NBP7) Pfam (PF05922)	Homo sapiens (Human)	Neural apoptosis-regulated convertase 1,NARC-1,Proprotein convertase 9,PC9,Subtilisin/kexin-like protease PC9
2	B (B)	Proprotein convertase subtilisin/kexin type 9	polymer	548	58548.9	1	UniProt (Q8NBP7) Pfam (PF00082) Pfam (PF18459) Pfam (PF18464) Pfam (PF18463)	Homo sapiens (Human)	Neural apoptosis-regulated convertase 1,NARC-1,Proprotein convertase 9,PC9,Subtilisin/kexin-like protease PC9
3	C (H)	Fab33 heavy chain	polymer	228	24138.0	1		Homo sapiens (Human)
4	D (L)	Fab33 light chain	polymer	214	23294.9	1	UniProt (Q7Z3Y4) Pfam (PF07686) Pfam (PF07654)	Homo sapiens (Human)

Sequence modifications

B: 153 - 692 (UniProt: Q8NBP7)

PDB	External Database	Details
Ile 474	Val 474	variant
Glu 670	Gly 670	variant
His 693	-	expression tag
His 694	-	expression tag
His 695	-	expression tag
His 696	-	expression tag
His 697	-	expression tag
His 698	-	expression tag
His 699	-	expression tag
His 700	-	expression tag

L: 1 - 104 (PDB: 5VL7)
L: 105 - 214 (UniProt: Q7Z3Y4)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	123017.3
All*	Total formula weight	123017.3

*Water molecules are not included.