5VL7
PCSK9 complex with Fab33
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Proprotein convertase subtilisin/kexin type 9 | polymer | 152 | 17035.5 | 1 | UniProt (Q8NBP7) Pfam (PF05922) In PDB | Homo sapiens (Human) | Neural apoptosis-regulated convertase 1,NARC-1,Proprotein convertase 9,PC9,Subtilisin/kexin-like protease PC9 |
2 | B | Proprotein convertase subtilisin/kexin type 9 | polymer | 548 | 58548.9 | 1 | UniProt (Q8NBP7) Pfam (PF00082) Pfam (PF18459) Pfam (PF18464) Pfam (PF18463) In PDB | Homo sapiens (Human) | Neural apoptosis-regulated convertase 1,NARC-1,Proprotein convertase 9,PC9,Subtilisin/kexin-like protease PC9 |
3 | H | Fab33 heavy chain | polymer | 228 | 24138.0 | 1 | Homo sapiens (Human) | ||
4 | L | Fab33 light chain | polymer | 214 | 23294.9 | 1 | UniProt (Q7Z3Y4) Pfam (PF07686) Pfam (PF07654) In PDB | Homo sapiens (Human) |
Sequence modifications
B: 153 - 692 (UniProt: Q8NBP7)
L: 1 - 104 (PDB: 5VL7)
L: 105 - 214 (UniProt: Q7Z3Y4)
PDB | External Database | Details |
---|---|---|
Ile 474 | Val 474 | variant |
Glu 670 | Gly 670 | variant |
His 693 | - | expression tag |
His 694 | - | expression tag |
His 695 | - | expression tag |
His 696 | - | expression tag |
His 697 | - | expression tag |
His 698 | - | expression tag |
His 699 | - | expression tag |
His 700 | - | expression tag |
L: 105 - 214 (UniProt: Q7Z3Y4)
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 123017.3 | |
All* | Total formula weight | 123017.3 |