5VL7

PCSK9 complex with Fab33

Summary for 5VL7

Entry DOI	10.2210/pdb5vl7/pdb
Descriptor	Proprotein convertase subtilisin/kexin type 9, Fab33 heavy chain, Fab33 light chain, ... (4 entities in total)
Functional Keywords	immunoglobulin proprotein convertase, subtilisin, hydrolase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	123017.27
Authors	Eigenbrot, C.,Shia, S. (deposition date: 2017-04-25, release date: 2017-08-16, Last modification date: 2023-10-04)
Primary citation	Zhang, Y.,Ultsch, M.,Skelton, N.J.,Burdick, D.J.,Beresini, M.H.,Li, W.,Kong-Beltran, M.,Peterson, A.,Quinn, J.,Chiu, C.,Wu, Y.,Shia, S.,Moran, P.,Di Lello, P.,Eigenbrot, C.,Kirchhofer, D. Discovery of a cryptic peptide-binding site on PCSK9 and design of antagonists. Nat. Struct. Mol. Biol., 24:848-856, 2017 Cited by PubMed: 28825733 DOI: 10.1038/nsmb.3453 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.5 Å)

Structure validation