5VIC

Crystal structure of anti-Zika antibody Z004 bound to DENV-1 Envelope protein DIII

Summary for 5VIC

• Entry DOI: 10.2210/pdb5vic/pdb
• Related: 5vig
• Descriptor: Fab heavy chain, Fab light chain, Dengue 1 Envelope DIII domain (3 entities in total)
• Functional Keywords: antibody, fab, zika, dengue, recurrent, neutralizing, immune system
• Biological source: Homo sapiens (Human); More
• Cellular location: Secreted : P0DOX7; Protein C: Virion. Peptide pr: Secreted . Small envelope protein M: Virion membrane ; Multi-pass membrane protein. Envelope protein E: Virion membrane ; Multi-pass membrane protein. Non-structural protein 1: Secreted . Non-structural protein 2A-alpha: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Non-structural protein 2A: Host endoplasmic reticulum membrane ; Multi- pass membrane protein . Serine protease subunit NS2B: Host endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side . Serine protease NS3: Host endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side . Non-structural protein 4A: Host endoplasmic reticulum membrane ; Multi- pass membrane protein . Non-structural protein 4B: Host endoplasmic reticulum membrane ; Multi- pass membrane protein . RNA-directed RNA polymerase NS5: Host endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side : P17763
• Total number of polymer chains: 3
• Total formula weight: 59327.35

Authors

Keeffe, J.R.,West Jr., A.P.,Gristick, H.B.,Bjorkman, P.J. (deposition date: 2017-04-14, release date: 2017-05-03, Last modification date: 2017-05-17)

• Primary citation: Robbiani, D.F.,Bozzacco, L.,Keeffe, J.R.,Khouri, R.,Olsen, P.C.,Gazumyan, A.,Schaefer-Babajew, D.,Avila-Rios, S.,Nogueira, L.,Patel, R.,Azzopardi, S.A.,Uhl, L.F.K.,Saeed, M.,Sevilla-Reyes, E.E.,Agudelo, M.,Yao, K.H.,Golijanin, J.,Gristick, H.B.,Lee, Y.E.,Hurley, A.,Caskey, M.,Pai, J.,Oliveira, T.,Wunder, E.A.,Sacramento, G.,Nery, N.,Orge, C.,Costa, F.,Reis, M.G.,Thomas, N.M.,Eisenreich, T.,Weinberger, D.M.,de Almeida, A.R.P.,West, A.P.,Rice, C.M.,Bjorkman, P.J.,Reyes-Teran, G.,Ko, A.I.,MacDonald, M.R.,Nussenzweig, M.C.; Recurrent Potent Human Neutralizing Antibodies to Zika Virus in Brazil and Mexico.; Cell, 169:597-609.e11, 2017; PubMed: 28475892; DOI: 10.1016/j.cell.2017.04.024

Experimental method

X-RAY DIFFRACTION (3 Å)