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5NIU

Structure of human Programmed cell death 1 ligand 1 (PD-L1) with low molecular mass inhibitor

Summary for 5NIU
Entry DOI10.2210/pdb5niu/pdb
DescriptorProgrammed cell death 1 ligand 1, (2~{R})-2-[[2-[(3-cyanophenyl)methoxy]-4-[[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methyl-phenyl]methoxy]-5-methyl-phenyl]methylamino]-3-oxidanyl-propanoic acid, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywordspd-l1, pd-1, immune checkpoint, immune system
Biological sourceHomo sapiens (Human)
Cellular locationIsoform 1: Cell membrane ; Single-pass type I membrane protein . Isoform 2: Endomembrane system ; Single-pass type I membrane protein : Q9NZQ7
Total number of polymer chains4
Total formula weight60028.48
Authors
Zak, K.M.,Grudnik, P.,Skalniak, L.,Dubin, G.,Holak, T.A. (deposition date: 2017-03-27, release date: 2017-12-06, Last modification date: 2024-01-17)
Primary citationSkalniak, L.,Zak, K.M.,Guzik, K.,Magiera, K.,Musielak, B.,Pachota, M.,Szelazek, B.,Kocik, J.,Grudnik, P.,Tomala, M.,Krzanik, S.,Pyrc, K.,Domling, A.,Dubin, G.,Holak, T.A.
Small-molecule inhibitors of PD-1/PD-L1 immune checkpoint alleviate the PD-L1-induced exhaustion of T-cells.
Oncotarget, 8:72167-72181, 2017
Cited by
PubMed: 29069777
DOI: 10.18632/oncotarget.20050
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.01 Å)
Structure validation

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