5VL3

CD22 d1-d3 in complex with therapeutic Fab Epratuzumab

Summary for 5VL3

• Entry DOI: 10.2210/pdb5vl3/pdb
• Related: 5VKJ 5VKK 5VKM
• EMDB information: 8704 8705
• Descriptor: B-cell receptor CD22, Epratuzumab Fab Heavy Chain, Epratuzumab Fab Light Chain, ... (8 entities in total)
• Functional Keywords: therapeutic antibody, siglec, b cell, fab, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 12
• Total formula weight: 345472.70

Authors

Sicard, T.,Ereno-Orbea, J.,Julien, J.P. (deposition date: 2017-04-24, release date: 2017-10-11, Last modification date: 2020-07-29)

• Primary citation: Ereno-Orbea, J.,Sicard, T.,Cui, H.,Mazhab-Jafari, M.T.,Benlekbir, S.,Guarne, A.,Rubinstein, J.L.,Julien, J.P.; Molecular basis of human CD22 function and therapeutic targeting.; Nat Commun, 8:764-764, 2017; PubMed: 28970495; DOI: 10.1038/s41467-017-00836-6

Experimental method

X-RAY DIFFRACTION (3.1 Å)