5VL3
CD22 d1-d3 in complex with therapeutic Fab Epratuzumab
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | Q, R, S, T | B-cell receptor CD22 | polymer | 323 | 36802.4 | 4 | UniProt (P20273) Pfam (PF08205) Pfam (PF13927) In PDB | Homo sapiens (Human) | B-lymphocyte cell adhesion molecule,BL-CAM,Sialic acid-binding Ig-like lectin 2,Siglec-2,T-cell surface antigen Leu-14 |
2 | A, C, E, H | Epratuzumab Fab Heavy Chain | polymer | 222 | 24028.7 | 4 | UniProt (S6B291) Pfam (PF07686) Pfam (PF07654) In PDB | Mus musculus (Mouse) | |
3 | B, D, F, L | Epratuzumab Fab Light Chain | polymer | 222 | 24341.0 | 4 | UniProt (Q8TCD0) Pfam (PF07686) Pfam (PF07654) In PDB | Mus musculus (Mouse) | |
4 | G, J, M, O | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 4 | In PDB GlyTouCan (G42666HT) | |||
5 | I | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G22768VO) | |||
6 | K, P | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 2 | In PDB GlyTouCan (G81315DD) | |||
7 | N | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
8 | S | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) |
Sequence modifications
Q, R, S, T: 22 - 330 (UniProt: P20273)
A, C, E, H: -2 - 108 (PDB: 5VL3)
A, C, E, H: 109 - 217 (UniProt: S6B291)
B, D, F, L: -2 - 100 (PDB: 5VL3)
B, D, F, L: 101 - 215 (UniProt: Q8TCD0)
PDB | External Database | Details |
---|---|---|
Thr 18 | - | expression tag |
Gly 19 | - | expression tag |
Asp 20 | - | expression tag |
Ser 21 | - | expression tag |
Gln 67 | Asn 67 | engineered mutation |
Gln 112 | Asn 112 | engineered mutation |
Gln 135 | Asn 135 | engineered mutation |
Gln 164 | Asn 164 | engineered mutation |
Gly 331 | - | expression tag |
Gly 332 | - | expression tag |
Thr 333 | - | expression tag |
Lys 334 | - | expression tag |
His 335 | - | expression tag |
His 336 | - | expression tag |
His 337 | - | expression tag |
His 338 | - | expression tag |
His 339 | - | expression tag |
His 340 | - | expression tag |
A, C, E, H: 109 - 217 (UniProt: S6B291)
B, D, F, L: -2 - 100 (PDB: 5VL3)
B, D, F, L: 101 - 215 (UniProt: Q8TCD0)
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 12 |
Total formula weight | 340688.3 | |
Branched | Number of molecules | 8 |
Total formula weight | 4692.3 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 92.1 | |
All* | Total formula weight | 345472.7 |