5V52

Structure of TIGIT bound to nectin-2 (CD112)

Summary for 5V52

Entry DOI	10.2210/pdb5v52/pdb
Descriptor	T-cell immunoreceptor with Ig and ITIM domains, Nectin-2, GLYCEROL, ... (5 entities in total)
Functional Keywords	immune receptor, adhesion molecule, immunoglobulin fold, immune system
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	54385.84
Authors	Deuss, F.A.,Gully, B.S.,Rossjohn, J.,Berry, R. (deposition date: 2017-03-13, release date: 2017-05-24, Last modification date: 2023-10-04)
Primary citation	Deuss, F.A.,Gully, B.S.,Rossjohn, J.,Berry, R. Recognition of nectin-2 by the natural killer cell receptor T cell immunoglobulin and ITIM domain (TIGIT). J. Biol. Chem., 292:11413-11422, 2017 Cited by PubMed: 28515320 DOI: 10.1074/jbc.M117.786483 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.1 Å)

Structure validation