PDB: 1196 件ウェブページステータス検索Chemie searchBIRD

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7E33	Serotonin 1E (5-HT1E) receptor-Gi protein complex 分子名称: 3-(1-methylpiperidin-4-yl)-1H-indol-5-ol, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Xu, P, Huang, S, Zhang, H, Mao, C, Zhou, X.E, Shen, D.D, Jiang, Y, Zhang, Y, Xu, H.E. 登録日 2021-02-07 公開日 2021-04-14 最終更新日 2021-04-28 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Structural insights into the lipid and ligand regulation of serotonin receptors. Nature, 592, 2021
7E2Y	Serotonin-bound Serotonin 1A (5-HT1A) receptor-Gi protein complex 分子名称: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Xu, P, Huang, S, Zhang, H, Mao, C, Zhou, X.E, Shen, D.D, Jiang, Y, Zhang, Y, Xu, H.E. 登録日 2021-02-07 公開日 2021-04-14 最終更新日 2021-04-28 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structural insights into the lipid and ligand regulation of serotonin receptors. Nature, 592, 2021
7E2X	Apo serotonin 1A (5-HT1A) receptor-Gi protein complex 分子名称: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Xu, P, Huang, S, Zhang, H, Mao, C, Zhou, X.E, Shen, D.D, Jiang, Y, Zhang, Y, Xu, H.E. 登録日 2021-02-07 公開日 2021-04-14 最終更新日 2021-04-28 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structural insights into the lipid and ligand regulation of serotonin receptors. Nature, 592, 2021
7E2Z	Aripiprazole-bound serotonin 1A (5-HT1A) receptor-Gi protein complex 分子名称: 7-[4-[4-[2,3-bis(chloranyl)phenyl]piperazin-1-yl]butoxy]-3,4-dihydro-1H-quinolin-2-one, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Xu, P, Huang, S, Zhang, H, Mao, C, Zhou, X.E, Shen, D.D, Jiang, Y, Zhang, Y, Xu, H.E. 登録日 2021-02-07 公開日 2021-04-14 最終更新日 2021-04-28 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural insights into the lipid and ligand regulation of serotonin receptors. Nature, 592, 2021
7E32	Serotonin 1D (5-HT1D) receptor-Gi protein complex 分子名称: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Xu, P, Huang, S, Zhang, H, Mao, C, Zhou, X.E, Shen, D.D, Jiang, Y, Zhang, Y, Xu, H.E. 登録日 2021-02-07 公開日 2021-04-21 最終更新日 2021-04-28 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Structural insights into the lipid and ligand regulation of serotonin receptors. Nature, 592, 2021
7M8W	XFEL crystal structure of the prostaglandin D2 receptor CRTH2 in complex with 15R-methyl-PGD2 分子名称: 15R-methyl-prostaglandin D2, CITRATE ANION, Prostaglandin D2 receptor 2, ... 著者 Shiriaeva, A, Han, G.W, Cherezov, V. 登録日 2021-03-30 公開日 2021-08-25 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.61 Å) 主引用文献 Molecular basis for lipid recognition by the prostaglandin D 2 receptor CRTH2. Proc.Natl.Acad.Sci.USA, 118, 2021
7EIB	Cryo-EM structure of the type 1 bradykinin receptor in complex with the des-Arg10-kallidin and an Gq protein 分子名称: B1 bradykinin receptor, G subunit q (Gi1-Gq chimeric), Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Yin, Y, Jiang, Y. 登録日 2021-03-30 公開日 2021-10-13 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Molecular basis for kinin selectivity and activation of the human bradykinin receptors. Nat.Struct.Mol.Biol., 28, 2021
7EJ8	Structure of the alpha2A-adrenergic receptor GoA signaling complex bound to brimonidine 分子名称: Alpha-2A adrenergic receptor, Brimonidine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Xu, J, Cao, S, Liu, Z, Du, Y. 登録日 2021-04-01 公開日 2022-04-13 最終更新日 2022-10-26 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structural insights into ligand recognition, activation, and signaling of the alpha 2A adrenergic receptor. Sci Adv, 8, 2022
7EJ0	Structure of the alpha2A-adrenergic receptor GoA signaling complex 分子名称: Alpha-2A adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Xu, J, Cao, S, Liu, Z, Du, Y. 登録日 2021-04-01 公開日 2022-04-13 最終更新日 2022-10-26 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structural insights into ligand recognition, activation, and signaling of the alpha 2A adrenergic receptor. Sci Adv, 8, 2022
7EJA	Structure of the alpha2A-adrenergic receptor GoA signaling complex bound to dexmedetomidine 分子名称: 4-[(1~{S})-1-(2,3-dimethylphenyl)ethyl]-1~{H}-imidazole, Alpha-2A adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Xu, J, Cao, S, Liu, Z, Du, Y. 登録日 2021-04-01 公開日 2022-04-13 最終更新日 2023-11-29 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Structural insights into ligand recognition, activation, and signaling of the alpha 2A adrenergic receptor. Sci Adv, 8, 2022
7MBX	Human Cholecystokinin 1 receptor (CCK1R) Gs complex 分子名称: CHOLESTEROL HEMISUCCINATE, Cholecystokinin receptor type A, Cholecystokinin-8, ... 著者 Mobbs, J.I, Belousoff, M.J, Danev, R, Thal, D.M, Sexton, P.M. 登録日 2021-04-01 公開日 2021-05-26 最終更新日 2021-07-14 実験手法 ELECTRON MICROSCOPY (1.95 Å) 主引用文献 Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity. Plos Biol., 19, 2021
7MBY	Human Cholecystokinin 1 receptor (CCK1R) Gq chimera (mGsqi) complex 分子名称: CHOLESTEROL HEMISUCCINATE, Cholecystokinin receptor type A, Cholecystokinin-8, ... 著者 Mobbs, J.I, Belousoff, M.J, Danev, R, Thal, D.M, Sexton, P.M. 登録日 2021-04-01 公開日 2021-05-26 最終更新日 2021-07-14 実験手法 ELECTRON MICROSCOPY (2.44 Å) 主引用文献 Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity. Plos Biol., 19, 2021
7EJK	Structure of the alpha2A-adrenergic receptor GoA signaling complex bound to oxymetazoline 分子名称: Alpha-2A adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Xu, J, Cao, S, Liu, Z, Du, Y. 登録日 2021-04-02 公開日 2022-04-13 最終更新日 2022-10-26 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Structural insights into ligand recognition, activation, and signaling of the alpha 2A adrenergic receptor. Sci Adv, 8, 2022
7EJX	Structure of the GPR88-Gi1 signaling complex bound to a synthetic ligand 分子名称: (1R,2R)-N-[(2S,3S)-2-azanyl-3-methyl-pentyl]-N-[4-(4-propylphenyl)phenyl]-2-pyridin-2-yl-cyclopropane-1-carboxamide, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Xu, J, Chen, G, Liu, Z, Du, Y. 登録日 2021-04-02 公開日 2022-04-13 最終更新日 2022-10-26 実験手法 ELECTRON MICROSCOPY (2.4 Å) 主引用文献 Activation and allosteric regulation of the orphan GPR88-Gi1 signaling complex. Nat Commun, 13, 2022
7O7F	Structural basis of the activation of the CC chemokine receptor 5 by a chemokine agonist 分子名称: C-C chemokine receptor type 5, C-C motif chemokine 5, Fab antibody fragment heavy chain, ... 著者 Isaikina, P, Tsai, C.-J, Dietz, N.B, Pamula, F, Goldie, K.N, Schertler, G.F.X, Maier, T, Stahlberg, H, Deupi, X, Grzesiek, S. 登録日 2021-04-13 公開日 2021-06-30 最終更新日 2022-03-16 実験手法 ELECTRON MICROSCOPY (3.15 Å) 主引用文献 Structural basis of the activation of the CC chemokine receptor 5 by a chemokine agonist. Sci Adv, 7, 2021
7EO4	Cryo-EM of Sphingosine 1-phosphate receptor 1 / Gi complex bound to BAF312 分子名称: 1-[[4-[(~{E})-~{N}-[[4-cyclohexyl-3-(trifluoromethyl)phenyl]methoxy]-~{C}-methyl-carbonimidoyl]-2-ethyl-phenyl]methyl]azetidine-3-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 He, Y, Xu, Z, Ikuta, T, Inoue, A. 登録日 2021-04-21 公開日 2022-01-05 最終更新日 2022-03-16 実験手法 ELECTRON MICROSCOPY (2.86 Å) 主引用文献 Structural basis of sphingosine-1-phosphate receptor 1 activation and biased agonism. Nat.Chem.Biol., 18, 2022
7EO2	Cryo-EM of Sphingosine 1-phosphate receptor 1 / Gi complex bound to FTY720p 分子名称: (2~{S})-2-azanyl-4-(4-octylphenyl)-2-[[oxidanyl-bis(oxidanylidene)-$l^{6}-phosphanyl]oxymethyl]butan-1-ol, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 He, Y, Xu, Z, Ikuta, T. 登録日 2021-04-21 公開日 2022-01-05 最終更新日 2022-03-16 実験手法 ELECTRON MICROSCOPY (2.89 Å) 主引用文献 Structural basis of sphingosine-1-phosphate receptor 1 activation and biased agonism. Nat.Chem.Biol., 18, 2022
7MT8	Rhodopsin kinase (GRK1)-S5E/S488E/T489E in complex with rhodopsin 分子名称: RETINAL, Rhodopsin, Rhodopsin kinase GRK1, ... 著者 Chen, Q, Chen, C.-L, Tesmer, J.J.G. 登録日 2021-05-13 公開日 2021-07-07 最終更新日 2021-08-25 実験手法 ELECTRON MICROSCOPY (5.8 Å) 主引用文献 Structures of rhodopsin in complex with G-protein-coupled receptor kinase 1. Nature, 595, 2021
7MTB	Rhodopsin kinase (GRK1)-S5E/S488E/T489E in complex with rhodopsin and Fab6 分子名称: Fab6 heavy chain, Fab6 light chain, RETINAL, ... 著者 Chen, Q, Chen, C.-L, Tesmer, J.J.G. 登録日 2021-05-13 公開日 2021-07-07 最終更新日 2021-08-25 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Structures of rhodopsin in complex with G-protein-coupled receptor kinase 1. Nature, 595, 2021
7MTA	Rhodopsin kinase (GRK1)-S5E/S488E/T489E in complex with rhodopsin and Fab1 分子名称: Fab1 Heavy chain, Fab1 Light chain, RETINAL, ... 著者 Chen, Q, Chen, C.-L, Tesmer, J.J.G. 登録日 2021-05-13 公開日 2021-07-07 最終更新日 2021-08-25 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 Structures of rhodopsin in complex with G-protein-coupled receptor kinase 1. Nature, 595, 2021
7MT9	Rhodopsin kinase (GRK1) in complex with rhodopsin 分子名称: RETINAL, Rhodopsin, Rhodopsin kinase GRK1, ... 著者 Chen, Q, Chen, C.-L, Tesmer, J.J.G. 登録日 2021-05-13 公開日 2021-07-07 最終更新日 2021-08-25 実験手法 ELECTRON MICROSCOPY (7 Å) 主引用文献 Structures of rhodopsin in complex with G-protein-coupled receptor kinase 1. Nature, 595, 2021
7EUO	The structure of formyl peptide receptor 1 in complex with Gi and peptide agonist fMLF 分子名称: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Wang, X.K, Chen, G, Liao, Q.W, Du, Y, Hu, H.L, Ye, D.Q. 登録日 2021-05-18 公開日 2022-05-25 最終更新日 2022-12-07 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Structural basis for recognition of N-formyl peptides as pathogen-associated molecular patterns. Nat Commun, 13, 2022
7EW3	Cryo-EM structure of S1P-bound Sphingosine 1-phosphate receptor 3 in complex with Gi protein 分子名称: (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Zhao, C, Wang, W, Wang, H.L, Shao, Z.H. 登録日 2021-05-24 公開日 2021-09-29 最終更新日 2022-02-16 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural insights into sphingosine-1-phosphate recognition and ligand selectivity of S1PR3-Gi signaling complexes. Cell Res., 32, 2022
7EW7	Cryo-EM structure of SEW2871-bound Sphingosine-1-phosphate receptor 1 in complex with Gi protein 分子名称: 5-[4-phenyl-5-(trifluoromethyl)thiophen-2-yl]-3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazole, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Jia, G.W, Yuan, Y, Su, Z.M, Shao, Z.H. 登録日 2021-05-24 公開日 2021-09-29 最終更新日 2022-02-16 実験手法 ELECTRON MICROSCOPY (3.27 Å) 主引用文献 Structures of signaling complexes of lipid receptors S1PR1 and S1PR5 reveal mechanisms of activation and drug recognition. Cell Res., 31, 2021
7EVY	Cryo-EM structure of siponimod -bound Sphingosine-1-phosphate receptor 1 in complex with Gi protein 分子名称: 1-[[4-[(~{E})-~{N}-[[4-cyclohexyl-3-(trifluoromethyl)phenyl]methoxy]-~{C}-methyl-carbonimidoyl]-2-ethyl-phenyl]methyl]azetidine-3-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Jia, G.W, Yuan, Y, Su, Z.M, Shao, Z.H. 登録日 2021-05-24 公開日 2021-09-29 最終更新日 2022-02-16 実験手法 ELECTRON MICROSCOPY (2.98 Å) 主引用文献 Structures of signaling complexes of lipid receptors S1PR1 and S1PR5 reveal mechanisms of activation and drug recognition. Cell Res., 31, 2021

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