7E2Z

Aripiprazole-bound serotonin 1A (5-HT1A) receptor-Gi protein complex

Summary for 7E2Z

• Entry DOI: 10.2210/pdb7e2z/pdb
• EMDB information: 30973
• Descriptor: Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (7 entities in total)
• Functional Keywords: serotonin, 5-ht1a, gpcr, complex, g protein, gi, aripiprazole, signaling protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 149062.44

Authors

Xu, P.,Huang, S.,Zhang, H.,Mao, C.,Zhou, X.E.,Shen, D.D.,Jiang, Y.,Zhang, Y.,Xu, H.E. (deposition date: 2021-02-07, release date: 2021-04-14, Last modification date: 2021-04-28)

• Primary citation: Xu, P.,Huang, S.,Zhang, H.,Mao, C.,Zhou, X.E.,Cheng, X.,Simon, I.A.,Shen, D.D.,Yen, H.Y.,Robinson, C.V.,Harpsoe, K.,Svensson, B.,Guo, J.,Jiang, H.,Gloriam, D.E.,Melcher, K.,Jiang, Y.,Zhang, Y.,Xu, H.E.; Structural insights into the lipid and ligand regulation of serotonin receptors.; Nature, 592:469-473, 2021; PubMed: 33762731; DOI: 10.1038/s41586-021-03376-8

Experimental method

ELECTRON MICROSCOPY (3.1 Å)