2LP1
 
 | | The solution NMR structure of the transmembrane C-terminal domain of the amyloid precursor protein (C99) | | 分子名称: | C99 | | 著者 | Barrett, P.J, Song, Y, Van Horn, W.D, Hustedt, E.J, Schafer, J.M, Hadziselimovic, A, Beel, A.J, Sanders, C.R. | | 登録日 | 2012-01-30 | | 公開日 | 2012-06-06 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The amyloid precursor protein has a flexible transmembrane domain and binds cholesterol.
Science, 336, 2012
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6NB9
 | | Amyloid-Beta (20-34) with L-isoaspartate 23 | | 分子名称: | Amyloid-beta A4 protein | | 著者 | Sawaya, M.R, Warmack, R.A, Boyer, D.R, Zee, C.T, Richards, L.S, Cascio, D, Gonen, T, Clarke, S.G, Eisenberg, D.S. | | 登録日 | 2018-12-06 | | 公開日 | 2019-08-07 | | 最終更新日 | 2022-09-07 | | 実験手法 | ELECTRON CRYSTALLOGRAPHY (1.05 Å) | | 主引用文献 | Structure of amyloid-beta (20-34) with Alzheimer's-associated isomerization at Asp23 reveals a distinct protofilament interface.
Nat Commun, 10, 2019
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3DXE
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3DXC
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3DXD
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8AZT
 | | Type II amyloid-beta 42 filaments from high-spin supernatants of aqueous extracts from Alzheimer's disease brains | ABeta42 | | 分子名称: | Amyloid-beta precursor protein | | 著者 | Yang, Y, Stern, M.A, Meunier, L.A, Liu, W, Cai, Y.Q, Ericsson, M, Liu, L, Selkoe, J.D, Goedert, M, Scheres, H.W.S. | | 登録日 | 2022-09-06 | | 公開日 | 2022-11-02 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Abundant A beta fibrils in ultracentrifugal supernatants of aqueous extracts from Alzheimer's disease brains.
Neuron, 111, 2023
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8AZS
 | | Type I amyloid-beta 42 filaments from high-spin supernatants of aqueous extracts from Alzheimer's disease brains | ABeta42 | | 分子名称: | Amyloid-beta precursor protein | | 著者 | Yang, Y, Stern, M.A, Meunier, L.A, Liu, W, Cai, Y.Q, Ericsson, M, Liu, L, Selkoe, J.D, Goedert, M, Scheres, H.W.S. | | 登録日 | 2022-09-06 | | 公開日 | 2022-11-02 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Abundant A beta fibrils in ultracentrifugal supernatants of aqueous extracts from Alzheimer's disease brains.
Neuron, 111, 2023
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6YHF
 | | Solution NMR Structure of APP TMD | | 分子名称: | Amyloid-beta precursor protein | | 著者 | Silber, M, Muhle-Goll, C. | | 登録日 | 2020-03-29 | | 公開日 | 2020-12-09 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Altered Hinge Conformations in APP Transmembrane Helix Mutants May Affect Enzyme-Substrate Interactions of gamma-Secretase.
Acs Chem Neurosci, 11, 2020
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7Q4M
 | | Type II beta-amyloid 42 Filaments from Human Brain | | 分子名称: | Amyloid-beta precursor protein, UNKNOWN ATOM OR ION | | 著者 | Yang, Y, Arseni, D, Zhang, W, Huang, M, Lovestam, S.K.A, Schweighauser, M, Kotecha, A, Murzin, A.G, Peak-Chew, S.Y, Macdonald, J, Lavenir, I, Garringer, H.J, Gelpi, E, Newell, K.L, Kovacs, G.G, Vidal, R, Ghetti, B, Falcon, B, Scheres, S.H.W, Goedert, M. | | 登録日 | 2021-11-01 | | 公開日 | 2021-11-24 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Cryo-EM structures of amyloid-beta 42 filaments from human brains.
Science, 375, 2022
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7Q4B
 | | Type I beta-amyloid 42 Filaments from Human Brain | | 分子名称: | Amyloid-beta precursor protein, UNKNOWN ATOM OR ION | | 著者 | Yang, Y, Arseni, D, Zhang, W, Huang, M, Lovestam, S.K.A, Schweighauser, M, Kotecha, A, Murzin, A.G, Peak-Chew, S.Y, Macdonald, J, Lavenir, I, Garringer, H.J, Gelpi, E, Newell, K.L, Kovacs, G.G, Vidal, R, Ghetti, B, Falcon, B, Scheres, S.H.W, Goedert, M. | | 登録日 | 2021-10-30 | | 公開日 | 2021-11-24 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | | 主引用文献 | Cryo-EM structures of amyloid-beta 42 filaments from human brains.
Science, 375, 2022
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6YHI
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6YHO
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6YHP
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6YHX
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8FF2
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8FF3
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8X54
 | | Cryo-EM structure of human gamma-secretase in complex with APP-C99 | | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Guo, X, Yan, C, Lei, J, Zhou, R, Shi, Y. | | 登録日 | 2023-11-16 | | 公開日 | 2024-05-29 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Molecular mechanism of substrate recognition and cleavage by human gamma-secretase.
Science, 384, 2024
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8X52
 | | Cryo-EM structure of human gamma-secretase in complex with Abeta49 | | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Guo, X, Yan, C, Lei, J, Zhou, R, Shi, Y. | | 登録日 | 2023-11-16 | | 公開日 | 2024-05-29 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Molecular mechanism of substrate recognition and cleavage by human gamma-secretase.
Science, 384, 2024
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8X53
 | | Cryo-EM structure of human gamma-secretase in complex with Abeta46 | | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Guo, X, Yan, C, Lei, J, Zhou, R, Shi, Y. | | 登録日 | 2023-11-16 | | 公開日 | 2024-05-29 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Molecular mechanism of substrate recognition and cleavage by human gamma-secretase.
Science, 384, 2024
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6GFI
 | | Structure of Human Mesotrypsin in complex with APPI variant T11V/M17R/I18F/F34V | | 分子名称: | 1,2-ETHANEDIOL, Amyloid-beta A4 protein, PRSS3 protein | | 著者 | Shahar, A, Cohen, I, Radisky, E, Papo, N, Naftaly, S. | | 登録日 | 2018-04-30 | | 公開日 | 2018-09-12 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Mapping protein selectivity landscapes using multi-target selective screening and next-generation sequencing of combinatorial libraries.
Nat Commun, 9, 2018
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1U37
 | | Auto-inhibition Mechanism of X11s/Mints Family Scaffold Proteins Revealed by the Closed Conformation of the Tandem PDZ Domains | | 分子名称: | amyloid beta A4 precursor protein-binding, family A, member 1 | | 著者 | Feng, W, Long, J.-F, Chan, L.-N, He, C, Fu, A, Xia, J, Ip, N.Y, Zhang, M. | | 登録日 | 2004-07-21 | | 公開日 | 2005-07-26 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Autoinhibition of X11/Mint scaffold proteins revealed by the closed conformation of the PDZ tandem
Nat.Struct.Mol.Biol., 12, 2005
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1U38
 | | Auto-inhibition Mechanism of X11s/Mints Family Scaffold Proteins Revealed by the Closed Conformation of the Tandem PDZ Domains | | 分子名称: | PVYI, amyloid beta A4 precursor protein-binding, family A, ... | | 著者 | Feng, W, Long, J.-F, Chan, L.-N, He, C, Fu, A, Xia, J, Ip, N.Y, Zhang, M. | | 登録日 | 2004-07-21 | | 公開日 | 2005-07-26 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Autoinhibition of X11/Mint scaffold proteins revealed by the closed conformation of the PDZ tandem
Nat.Struct.Mol.Biol., 12, 2005
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1X11
 | | X11 PTB DOMAIN | | 分子名称: | 13-MER PEPTIDE, X11 | | 著者 | Lee, C.-H, Zhang, Z, Kuriyan, J. | | 登録日 | 1997-07-28 | | 公開日 | 1998-01-14 | | 最終更新日 | 2024-06-05 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Sequence-specific recognition of the internalization motif of the Alzheimer's amyloid precursor protein by the X11 PTB domain.
EMBO J., 16, 1997
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1AQC
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6XOV
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