8X52

Cryo-EM structure of human gamma-secretase in complex with Abeta49

Summary for 8X52

• Entry DOI: 10.2210/pdb8x52/pdb
• EMDB information: 38059
• Descriptor: Amyloid-beta precursor protein, CHOLESTEROL, Nicastrin, ... (10 entities in total)
• Functional Keywords: intramembrane protease, gamma-secretase, presenilin-1, membrane protein, membrane protein-hydrolase complex
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 192756.36

Authors

Guo, X.,Yan, C.,Lei, J.,Zhou, R.,Shi, Y. (deposition date: 2023-11-16, release date: 2024-05-29, Last modification date: 2024-06-19)

• Primary citation: Guo, X.,Li, H.,Yan, C.,Lei, J.,Zhou, R.,Shi, Y.; Molecular mechanism of substrate recognition and cleavage by human gamma-secretase.; Science, 384:1091-1095, 2024; PubMed: 38843321; DOI: 10.1126/science.adn5820

Experimental method

ELECTRON MICROSCOPY (2.9 Å)