8AZS

Type I amyloid-beta 42 filaments from high-spin supernatants of aqueous extracts from Alzheimer's disease brains | ABeta42

Summary for 8AZS

Entry DOI	10.2210/pdb8azs/pdb
EMDB information	15770
Descriptor	Amyloid-beta precursor protein (1 entity in total)
Functional Keywords	amyloid, filaments, abeta42, amyloid-beta, cryo-em, protein fibril
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	4520.09
Authors	Yang, Y.,Stern, M.A.,Meunier, L.A.,Liu, W.,Cai, Y.Q.,Ericsson, M.,Liu, L.,Selkoe, J.D.,Goedert, M.,Scheres, H.W.S. (deposition date: 2022-09-06, release date: 2022-11-02, Last modification date: 2024-07-24)
Primary citation	Stern, A.M.,Yang, Y.,Jin, S.,Yamashita, K.,Meunier, A.L.,Liu, W.,Cai, Y.,Ericsson, M.,Liu, L.,Goedert, M.,Scheres, S.H.W.,Selkoe, D.J. Abundant A beta fibrils in ultracentrifugal supernatants of aqueous extracts from Alzheimer's disease brains. Neuron, 111:2012-, 2023 Cited by PubMed: 37167969 DOI: 10.1016/j.neuron.2023.04.007 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.9 Å)

Structure validation