1HRF
 
 | | SOLUTION STRUCTURE OF THE EPIDERMAL GROWTH FACTOR-LIKE DOMAIN OF HEREGULIN-ALPHA, A LIGAND FOR P180ERB4 | | 分子名称: | HEREGULIN ALPHA | | 著者 | Nagata, K, Kohda, D, Hatanaka, H, Ichikawa, S, Inagaki, F. | | 登録日 | 1994-07-21 | | 公開日 | 1994-10-15 | | 最終更新日 | 2017-11-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of the epidermal growth factor-like domain of heregulin-alpha, a ligand for p180erbB-4.
EMBO J., 13, 1994
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5W58
 | | Crystal Complex of Cyclooxygenase-2: (S)-ARN-2508 (a dual COX and FAAH inhibitor) | | 分子名称: | (2S)-2-{2-fluoro-3'-[(hexylcarbamoyl)oxy][1,1'-biphenyl]-4-yl}propanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Xu, S, Goodman, M.C, Banerjee, S, Piomelli, D, Marnett, L.J. | | 登録日 | 2017-06-14 | | 公開日 | 2018-01-31 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.267 Å) | | 主引用文献 | Dual cyclooxygenase-fatty acid amide hydrolase inhibitor exploits novel binding interactions in the cyclooxygenase active site.
J. Biol. Chem., 293, 2018
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7OM4
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4IBL
 | | Rubidium Sites in Blood Coagulation Factor VIIa | | 分子名称: | BENZAMIDINE, CALCIUM ION, CHLORIDE ION, ... | | 著者 | Vadivel, K, Schmidt, A, Cascio, D, Padmanabhan, K, Bajaj, S.P. | | 登録日 | 2012-12-08 | | 公開日 | 2014-04-16 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structure of human factor VIIa-soluble tissue factor with calcium, magnesium and rubidium
Acta Crystallogr.,Sect.D, D77, 2021
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7MN8
 | | Structure of the HER2/HER3/NRG1b Heterodimer Extracellular Domain bound to Trastuzumab Fab | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform 6 of Pro-neuregulin-1, ... | | 著者 | Diwanji, D, Trenker, R, Verba, K.A, Jura, N. | | 登録日 | 2021-04-30 | | 公開日 | 2021-11-10 | | 最終更新日 | 2021-12-22 | | 実験手法 | ELECTRON MICROSCOPY (3.45 Å) | | 主引用文献 | Structures of the HER2-HER3-NRG1 beta complex reveal a dynamic dimer interface.
Nature, 600, 2021
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6V3R
 | | Crystal structure of murine cycloxygenase in complex with a harmaline analog, 4,9-dihydro-3H-pyrido[3,4-b]indole | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 9-[(4-chlorophenyl)methyl]-6-methoxy-1-methyl-4,9-dihydro-3H-beta-carboline, ... | | 著者 | Xu, S, Uddin, M.J, Banerjee, S, Marnett, L.J. | | 登録日 | 2019-11-26 | | 公開日 | 2020-02-26 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.66 Å) | | 主引用文献 | Harmaline Analogs as Substrate-Selective Cyclooxygenase-2 Inhibitors.
Acs Med.Chem.Lett., 11, 2020
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8U4L
 | | Structure of the HER2/HER4/NRG1b Heterodimer Extracellular Domain | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform 6 of Pro-neuregulin-1, ... | | 著者 | Trenker, R, Diwanji, D, Bingham, T, Verba, K.A, Jura, N. | | 登録日 | 2023-09-10 | | 公開日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (3.31 Å) | | 主引用文献 | Structure of the HER2/HER4/NRG1b Heterodimer Extracellular Domain
To Be Published
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8U4I
 | | Structure of the HER4/NRG1b Homodimer Extracellular Domain | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform 6 of Pro-neuregulin-1, ... | | 著者 | Trenker, R, Diwanji, D, Bingham, T, Verba, K.A, Jura, N. | | 登録日 | 2023-09-10 | | 公開日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (3.38 Å) | | 主引用文献 | Structure of the HER2/HER4/NRG1b Heterodimer Extracellular Domain
To Be Published
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8OS5
 | | Crystal structure of the Factor XII heavy chain reveals an interlocking dimer with a FnII to kringle domain interaction | | 分子名称: | Coagulation factor XII-Mie | | 著者 | Li, C, Saleem, M, Kaira, B.G, Brown, A, Wilson, C, Philippou, H, Emsley, J. | | 登録日 | 2023-04-18 | | 公開日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | Factor XII and kininogen asymmetric assembly with gC1qR/C1QBP/P32 is governed by allostery.
Blood, 136, 2020
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8HGO
 | | The EGF-bound EGFR/HER2 ectodomain complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Epidermal growth factor, ... | | 著者 | Zhang, Z, Bai, X. | | 登録日 | 2022-11-15 | | 公開日 | 2023-02-08 | | 最終更新日 | 2023-03-01 | | 実験手法 | ELECTRON MICROSCOPY (3.31 Å) | | 主引用文献 | Structure and dynamics of the EGFR/HER2 heterodimer.
Cell Discov, 9, 2023
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8HGS
 | | The EGF-bound EGFR ectodomain homodimer | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Epidermal growth factor receptor, Pro-epidermal growth factor, ... | | 著者 | Zhang, Z, Bai, X. | | 登録日 | 2022-11-15 | | 公開日 | 2023-02-15 | | 最終更新日 | 2023-03-01 | | 実験手法 | ELECTRON MICROSCOPY (3.81 Å) | | 主引用文献 | Structure and dynamics of the EGFR/HER2 heterodimer.
Cell Discov, 9, 2023
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8S9P
 | | 1:1:1 agrin/LRP4/MuSK complex | | 分子名称: | Agrin, Low-density lipoprotein receptor-related protein 4, Muscle, ... | | 著者 | Xie, T, Xu, G.J, Liu, Y, Quade, B, Lin, W.C, Bai, X.C. | | 登録日 | 2023-03-29 | | 公開日 | 2023-05-17 | | 最終更新日 | 2023-06-14 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Structural insights into the assembly of the agrin/LRP4/MuSK signaling complex.
Proc.Natl.Acad.Sci.USA, 120, 2023
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7BMI
 | | Aspartyl/Asparaginyl beta-hydroxylase (AspH) oxygenase and TPR domains in complex with manganese, 3-fluoropyridine-2,4-dicarboxylic acid, and factor X substrate peptide fragment (39mer-4Ser) | | 分子名称: | 3-fluoranylpyridine-2,4-dicarboxylic acid, Aspartyl/asparaginyl beta-hydroxylase, Coagulation factor X, ... | | 著者 | Nakashima, Y, Brewitz, L, Schofield, C.J. | | 登録日 | 2021-01-20 | | 公開日 | 2021-06-02 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.66 Å) | | 主引用文献 | Fluorinated derivatives of pyridine-2,4-dicarboxylate are potent inhibitors of human 2-oxoglutarate dependent oxygenases
J Fluor Chem, 247, 2021
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7BMJ
 | | Aspartyl/Asparaginyl beta-hydroxylase (AspH) oxygenase and TPR domains in complex with manganese, 5-fluoropyridine-2,4-dicarboxylic acid, and factor X substrate peptide fragment (39mer-4Ser) | | 分子名称: | 5-fluoranylpyridine-2,4-dicarboxylic acid, Aspartyl/asparaginyl beta-hydroxylase, Coagulation factor X, ... | | 著者 | Nakashima, Y, Brewitz, L, Schofield, C.J. | | 登録日 | 2021-01-20 | | 公開日 | 2021-06-02 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Fluorinated derivatives of pyridine-2,4-dicarboxylate are potent inhibitors of human 2-oxoglutarate dependent oxygenases
J Fluor Chem, 247, 2021
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5MVX
 | | Human DLL4 C2-EGF3 | | 分子名称: | Delta-like protein 4, alpha-L-fucopyranose | | 著者 | Suckling, R.J, Handford, P.A, Lea, S.M. | | 登録日 | 2017-01-17 | | 公開日 | 2017-06-14 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.17 Å) | | 主引用文献 | Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands.
EMBO J., 36, 2017
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5MW7
 | | Human Jagged2 C2-EGF3 | | 分子名称: | Protein jagged-2, alpha-L-fucopyranose | | 著者 | Suckling, R.J, Handford, P.A, Lea, S.M. | | 登録日 | 2017-01-18 | | 公開日 | 2017-06-14 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands.
EMBO J., 36, 2017
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5MWB
 | | Human Notch-2 EGF11-13 | | 分子名称: | CALCIUM ION, Neurogenic locus notch homolog protein 2, alpha-L-fucopyranose, ... | | 著者 | Suckling, R.J, Handford, P.A, Lea, S.M. | | 登録日 | 2017-01-18 | | 公開日 | 2017-06-14 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | | 主引用文献 | Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands.
EMBO J., 36, 2017
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7E6J
 | | Aspartyl/Asparaginyl beta-hydroxylase (AspH) H725A in complex with Factor X peptide fragment (39mer-4Ser) | | 分子名称: | Aspartyl/asparaginyl beta-hydroxylase, GLYCEROL, PROPANOIC ACID, ... | | 著者 | Nakashima, Y, Brasnett, A, Brewitz, L, Schofield, C.J. | | 登録日 | 2021-02-22 | | 公開日 | 2021-06-30 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Human Oxygenase Variants Employing a Single Protein Fe II Ligand Are Catalytically Active.
Angew.Chem.Int.Ed.Engl., 60, 2021
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1CVU
 | | CRYSTAL STRUCTURE OF ARACHIDONIC ACID BOUND TO THE CYCLOOXYGENASE ACTIVE SITE OF COX-2 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ARACHIDONIC ACID, ... | | 著者 | Kiefer, J.R, Pawlitz, J.L, Moreland, K.T, Stegeman, R.A, Gierse, J.K, Stevens, A.M, Goodwin, D.C, Rowlinson, S.W, Marnett, L.J, Stallings, W.C, Kurumbail, R.G. | | 登録日 | 1999-08-24 | | 公開日 | 2000-05-16 | | 最終更新日 | 2021-11-03 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural insights into the stereochemistry of the cyclooxygenase reaction.
Nature, 405, 2000
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6OFY
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1CX2
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8CN9
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1DAN
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1DDX
 | | CRYSTAL STRUCTURE OF A MIXTURE OF ARACHIDONIC ACID AND PROSTAGLANDIN BOUND TO THE CYCLOOXYGENASE ACTIVE SITE OF COX-2: PROSTAGLANDIN STRUCTURE | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 7-[6-(3-HYDROPEROXY-OCT-1-ENYL)-2,3-DIOXA-BICYCLO[2.2.1]HEPT-5-YL]-HEPT-5-ENOIC ACID, ... | | 著者 | Kiefer, J.R, Pawlitz, J.L, Moreland, K.T, Stegeman, R.A, Gierse, J.K, Stevens, A.M, Goodwin, D.C, Rowlinson, S.W, Marnett, L.J, Stallings, W.C, Kurumbail, R.G. | | 登録日 | 1999-11-11 | | 公開日 | 2000-05-16 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structural insights into the stereochemistry of the cyclooxygenase reaction.
Nature, 405, 2000
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3CFW
 | | L-selectin lectin and EGF domains | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, L-selectin, ... | | 著者 | Mehta, P, Oganesyan, V, Terzyan, S, Mather, T, McEver, R.P. | | 登録日 | 2008-03-04 | | 公開日 | 2008-03-18 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Glycan Bound to the Selectin Low Affinity State Engages Glu-88 to Stabilize the High Affinity State under Force.
J.Biol.Chem., 292, 2017
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