5COX

UNINHIBITED MOUSE CYCLOOXYGENASE-2 (PROSTAGLANDIN SYNTHASE-2)

Summary for 5COX

DescriptorCYCLOOXYGENASE-2, N-ACETYL-D-GLUCOSAMINE, PROTOPORPHYRIN IX CONTAINING FE (3 entities in total)
Functional Keywordsperoxidase, dioxygenase, cyclooxygenase, nonsteroidal antiinflammatory drugs, inflammation, arthritis, prostaglandin, prostaglandin synthase, oxidoreductase
Biological sourceMus musculus (house mouse)
Cellular locationMicrosome membrane; Peripheral membrane protein Q05769
Total number of polymer chains4
Total molecular weight274395.32
Authors
Kurumbail, R.,Stallings, W. (deposition date: 1996-12-18, release date: 1997-12-24, Last modification date: 2011-07-13)
Primary citation
Kurumbail, R.G.,Stevens, A.M.,Gierse, J.K.,McDonald, J.J.,Stegeman, R.A.,Pak, J.Y.,Gildehaus, D.,Miyashiro, J.M.,Penning, T.D.,Seibert, K.,Isakson, P.C.,Stallings, W.C.
Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents.
Nature, 384:644-648, 1996
PubMed: 8967954 (PDB entries with the same primary citation)
DOI: 10.1038/384644a0
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliers0.253394.5%15.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution