7MN8

Structure of the HER2/HER3/NRG1b Heterodimer Extracellular Domain bound to Trastuzumab Fab

Summary for 7MN8

• Entry DOI: 10.2210/pdb7mn8/pdb
• Related: 7MN5 7MN6
• EMDB information: 23918
• Descriptor: Receptor tyrosine-protein kinase erbB-3, Isoform 6 of Pro-neuregulin-1, membrane-bound isoform, Receptor tyrosine-protein kinase erbB-2,Maltose/maltodextrin-binding periplasmic protein, ... (8 entities in total)
• Functional Keywords: complex, receptor tyrosine kinase, herceptin, trastuzumab, signaling protein, signaling protein-immune system complex, signaling protein/immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 5
• Total formula weight: 340885.12

Authors

Diwanji, D.,Trenker, R.,Verba, K.A.,Jura, N. (deposition date: 2021-04-30, release date: 2021-11-10, Last modification date: 2021-12-22)

• Primary citation: Diwanji, D.,Trenker, R.,Thaker, T.M.,Wang, F.,Agard, D.A.,Verba, K.A.,Jura, N.; Structures of the HER2-HER3-NRG1 beta complex reveal a dynamic dimer interface.; Nature, 600:339-343, 2021; PubMed: 34759323; DOI: 10.1038/s41586-021-04084-z

Experimental method

ELECTRON MICROSCOPY (3.45 Å)