7MN5
Structure of the HER2/HER3/NRG1b Heterodimer Extracellular Domain
Summary for 7MN5
Entry DOI | 10.2210/pdb7mn5/pdb |
EMDB information | 23916 |
Descriptor | Receptor tyrosine-protein kinase erbB-3, Isoform 6 of Pro-neuregulin-1, membrane-bound isoform, Receptor tyrosine-protein kinase erbB-2,Maltose/maltodextrin-binding periplasmic protein, ... (6 entities in total) |
Functional Keywords | complex, receptor tyrosine kinase, signaling protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 290801.57 |
Authors | Diwanji, D.,Trenker, R.,Verba, K.A.,Jura, N. (deposition date: 2021-04-30, release date: 2021-10-27, Last modification date: 2021-12-22) |
Primary citation | Diwanji, D.,Trenker, R.,Thaker, T.M.,Wang, F.,Agard, D.A.,Verba, K.A.,Jura, N. Structures of the HER2-HER3-NRG1 beta complex reveal a dynamic dimer interface. Nature, 600:339-343, 2021 Cited by PubMed: 34759323DOI: 10.1038/s41586-021-04084-z PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.93 Å) |
Structure validation
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