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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7MN5

Structure of the HER2/HER3/NRG1b Heterodimer Extracellular Domain

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)		Receptor tyrosine-protein kinase erbB-3polymer1066117852.71UniProt (P21860)
Pfam (PF01030)
Pfam (PF00757)
Pfam (PF14843)
Pfam (PF07714)		Homo sapiens (Human)Proto-oncogene-like protein c-ErbB-3,Tyrosine kinase-type cell surface receptor HER3
2B
(H)		Isoform 6 of Pro-neuregulin-1, membrane-bound isoformpolymer879748.91UniProt (Q02297-6)
Pfam (PF00008)
UniProt (by SIFTS) (Q02297)		Homo sapiens (Human)Pro-NRG1
3C
(B)		Receptor tyrosine-protein kinase erbB-2,Maltose/maltodextrin-binding periplasmic proteinpolymer1455160496.51UniProt (P04626)
UniProt (P0AEX9)
Pfam (PF21314)
Pfam (PF07714)
Pfam (PF01547)
Pfam (PF01030)
Pfam (PF00757)
Pfam (PF14843)		Homo sapiens (Human)Metastatic lymph node gene 19 protein,MLN 19,Proto-oncogene Neu,Proto-oncogene c-ErbB-2,Tyrosine kinase-type cell surface receptor HER2,p185erbB2,MMBP,Maltodextrin-binding protein,Maltose-binding protein,MBP
4D
(C)		alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranosebranched748.71In PDB
GlyTouCan (G81315DD)
5E, F
(D, E)		2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranosebranched424.42In PDB
GlyTouCan (G42666HT)
6G, H, I, J, K
(A, B)		2-acetamido-2-deoxy-beta-D-glucopyranosenon-polymer221.25Chemie (NAG)
Sequence modifications
A: 1 - 1021 (UniProt: P21860)
PDBExternal DatabaseDetails
Arg 809Gln 809conflict
Gly 928Glu 928conflict
Gly 1022-expression tag
Gly 1023-expression tag
Ser 1024-expression tag
Leu 1025-expression tag
Glu 1026-expression tag
Val 1027-expression tag
Leu 1028-expression tag
Phe 1029-expression tag
Gln 1030-expression tag
Gly 1031-expression tag
Pro 1032-expression tag
Ser 1033-expression tag
Ser 1034-expression tag
Pro 1035-expression tag
Ser 1036-expression tag
Ala 1037-expression tag
Trp 1038-expression tag
Ser 1039-expression tag
His 1040-expression tag
Pro 1041-expression tag
Gln 1042-expression tag
Phe 1043-expression tag
Glu 1044-expression tag
Lys 1045-expression tag
Gly 1046-expression tag
Gly 1047-expression tag
Gly 1048-expression tag
Ser 1049-expression tag
Gly 1050-expression tag
Gly 1051-expression tag
Gly 1052-expression tag
Ser 1053-expression tag
Gly 1054-expression tag
Gly 1055-expression tag
Ser 1056-expression tag
Ser 1057-expression tag
Ala 1058-expression tag
Trp 1059-expression tag
Ser 1060-expression tag
His 1061-expression tag
Pro 1062-expression tag
Gln 1063-expression tag
Phe 1064-expression tag
Glu 1065-expression tag
Lys 1066-expression tag
H: 177 - 236 (UniProt: Q02297-6)
PDBExternal DatabaseDetails
Gly 175-cloning artifact
Pro 176-cloning artifact
Gly 237-expression tag
Ser 238-expression tag
Gly 239-expression tag
Ser 240-expression tag
Gly 241-expression tag
Ser 242-expression tag
Asp 243-expression tag
Tyr 244-expression tag
Lys 245-expression tag
Asp 246-expression tag
Asp 247-expression tag
Asp 248-expression tag
Asp 249-expression tag
Lys 250-expression tag
Ala 251-expression tag
Ala 252-expression tag
Ala 253-expression tag
Leu 254-expression tag
Glu 255-expression tag
His 256-expression tag
His 257-expression tag
His 258-expression tag
His 259-expression tag
His 260-expression tag
His 261-expression tag
B: 1 - 1029 (UniProt: P04626)
PDBExternal DatabaseDetails
Asp 778Gly 778conflict
Gly 1030-linker
Gly 1031-linker
Ser 1032-linker
Leu 1033-linker
Glu 1034-linker
Val 1035-linker
Leu 1036-linker
Phe 1037-linker
Gln 1038-linker
Gly 1039-linker
Pro 1040-linker
Ser 1041-linker
Ser 1042-linker
Pro 1043-linker
Ser 1044-linker
Gly 1045-linker
Ser 1046-linker
Ser 1047-linker
Met 1048-linker
B: 1049 - 1414 (UniProt: P0AEX9)
PDBExternal DatabaseDetails
Asn 1415-expression tag
Ser 1416-expression tag
Ser 1417-expression tag
Ser 1418-expression tag
Ser 1419-expression tag
Gly 1420-expression tag
Pro 1421-expression tag
Ser 1422-expression tag
Ser 1423-expression tag
Pro 1424-expression tag
Ser 1425-expression tag
Ala 1426-expression tag
Trp 1427-expression tag
Ser 1428-expression tag
His 1429-expression tag
Pro 1430-expression tag
Gln 1431-expression tag
Phe 1432-expression tag
Glu 1433-expression tag
Lys 1434-expression tag
Gly 1435-expression tag
Gly 1436-expression tag
Gly 1437-expression tag
Ser 1438-expression tag
Gly 1439-expression tag
Gly 1440-expression tag
Gly 1441-expression tag
Ser 1442-expression tag
Gly 1443-expression tag
Gly 1444-expression tag
Ser 1445-expression tag
Ser 1446-expression tag
Ala 1447-expression tag
Trp 1448-expression tag
Ser 1449-expression tag
His 1450-expression tag
Pro 1451-expression tag
Gln 1452-expression tag
Phe 1453-expression tag
Glu 1454-expression tag
Lys 1455-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains3
Total formula weight288098.0
BranchedNumber of molecules3
Total formula weight1597.5
Non-Polymers*Number of molecules5
Total formula weight1106.0
All*Total formula weight290801.6
*Water molecules are not included.

227111

PDB entries from 2024-11-06

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