6V3R

Crystal structure of murine cycloxygenase in complex with a harmaline analog, 4,9-dihydro-3H-pyrido[3,4-b]indole

Summary for 6V3R

Entry DOI	10.2210/pdb6v3r/pdb
Descriptor	Prostaglandin G/H synthase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, PROTOPORPHYRIN IX CONTAINING FE, ... (7 entities in total)
Functional Keywords	prostaglandin g/h synthase 2, cyclooxygenase-2, oxidoreductase, inhibitor complex, membrane protein, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
Biological source	Mus musculus (Mouse)
Total number of polymer chains	4
Total formula weight	277204.12
Authors	Xu, S.,Uddin, M.J.,Banerjee, S.,Marnett, L.J. (deposition date: 2019-11-26, release date: 2020-02-26, Last modification date: 2023-10-11)
Primary citation	Uddin, M.J.,Xu, S.,Crews, B.C.,Aleem, A.M.,Ghebreselasie, K.,Banerjee, S.,Marnett, L.J. Harmaline Analogs as Substrate-Selective Cyclooxygenase-2 Inhibitors. Acs Med.Chem.Lett., 11:1881-1885, 2020 Cited by PubMed: 33062168 DOI: 10.1021/acsmedchemlett.9b00555 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.66 Å)

Structure validation