6OFY
Crystal Structure of Arachidonic Acid bound to V349I murine COX-2
Summary for 6OFY
| Entry DOI | 10.2210/pdb6ofy/pdb |
| Descriptor | Prostaglandin G/H synthase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose, PROTOPORPHYRIN IX CONTAINING CO, ... (7 entities in total) |
| Functional Keywords | arachidonic acid cyclooxygenase prostaglandin endoperoxide synthase, membrane protein, oxidoreductase |
| Biological source | Mus musculus (Mouse) |
| Total number of polymer chains | 2 |
| Total formula weight | 131207.35 |
| Authors | Malkowski, M.G. (deposition date: 2019-04-01, release date: 2020-02-05, Last modification date: 2023-10-11) |
| Primary citation | Dong, L.,Anderson, A.J.,Malkowski, M.G. Arg-513 and Leu-531 Are Key Residues Governing Time-Dependent Inhibition of Cyclooxygenase-2 by Aspirin and Celebrex. Biochemistry, 58:3990-4002, 2019 Cited by PubMed: 31469551DOI: 10.1021/acs.biochem.9b00659 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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